| Literature DB >> 15734329 |
Leonard J Corkery1, Henrianna Pang, Bradley B Schneider, Thomas R Covey, K W Michael Siu.
Abstract
An automated nanospray system based on chip technology (the NanoMate) was successfully interfaced to a modified Particle Discriminator Interface on a triple quadrupole mass spectrometer. A number of the interface parameters were optimized to improve the sampling efficiency for ions from the chip-based system. Analytical performance was assessed using a number of biochemicals as well as via a methodology for a pharmaceutical that passed validation as required by Good Laboratory Practices. Infusion analyses in flow rates <1 microL/min provided advantages in terms of throughput and sample consumption when compared to other methodologies based on liquid chromatography.Mesh：
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Year: 2005 PMID： 15734329 DOI： 10.1016/j.jasms.2004.11.018
Source DB: PubMed Journal: J Am Soc Mass Spectrom ISSN： 1044-0305 Impact factor: 3.109