Literature DB >> 15728923

A novel engineered peptide, a narrow-spectrum antibiotic, is effective against vancomycin-resistant Enterococcus faecalis.

Xiao-Qing Qiu1, Jie Zhang, He Wang, George Y Wu.   

Abstract

A novel antienterococcal peptide was prepared by fusing the enterococcal cCF10 pheromone to the channel-forming domain of colicin Ia, forming Enterococcus faecalis pheromonicin (PMC-EF). This peptide was bactericidal against vancomycin-resistant Enterococcus faecalis (VRE) organisms. Electron microscopy and vital dyes confirmed increased membrane permeability. All mice made bacteremic with VRE strains survived when they were treated with PMC-EF, while all controls died.

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Year:  2005        PMID： 15728923      PMCID： PMC549282          DOI： 10.1128/AAC.49.3.1184-1189.2005

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

1.  Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis.

Authors:  I T Paulsen; L Banerjei; G S A Myers; K E Nelson; R Seshadri; T D Read; D E Fouts; J A Eisen; S R Gill; J F Heidelberg; H Tettelin; R J Dodson; L Umayam; L Brinkac; M Beanan; S Daugherty; R T DeBoy; S Durkin; J Kolonay; R Madupu; W Nelson; J Vamathevan; B Tran; J Upton; T Hansen; J Shetty; H Khouri; T Utterback; D Radune; K A Ketchum; B A Dougherty; C M Fraser
Journal:  Science       Date:  2003-03-28       Impact factor: 47.728

Review 2.  Two-component signal transduction in Enterococcus faecalis.

Authors:  Lynn Hancock; Marta Perego
Journal:  J Bacteriol       Date:  2002-11       Impact factor: 3.490

3.  Modulation of virulence within a pathogenicity island in vancomycin-resistant Enterococcus faecalis.

Authors:  Nathan Shankar; Arto S Baghdayan; Michael S Gilmore
Journal:  Nature       Date:  2002-06-13       Impact factor: 49.962

4.  [Biosynthesis of a colicin and its mode of action].

Authors:  F JACOB; L SIMINOVITCH; E WOLLMAN
Journal:  Ann Inst Pasteur (Paris)       Date:  1952-09

5.  DNA and amino acid sequence analysis of structural and immunity genes of colicins Ia and Ib.

Authors:  J A Mankovich; C H Hsu; J Konisky
Journal:  J Bacteriol       Date:  1986-10       Impact factor: 3.490

6.  Colicin K acts by forming voltage-dependent channels in phospholipid bilayer membranes.

Authors:  S J Schein; B L Kagan; A Finkelstein
Journal:  Nature       Date:  1978-11-09       Impact factor: 49.962

7.  Two-component regulator of Enterococcus faecalis cytolysin responds to quorum-sensing autoinduction.

Authors:  Wolfgang Haas; Brett D Shepard; Michael S Gilmore
Journal:  Nature       Date:  2002-01-03       Impact factor: 49.962

8.  Alteration of the pH-dependent ion selectivity of the colicin E1 channel by site-directed mutagenesis.

Authors:  K S Jakes; C K Abrams; A Finkelstein; S L Slatin
Journal:  J Biol Chem       Date:  1990-04-25       Impact factor: 5.157

9.  Cell wall-associated protein A as a tool for immunolocalization of Staphylococcus aureus in infected human airway epithelium.

Authors:  E Mongodin; O Bajolet; J Hinnrasky; E Puchelle; S de Bentzmann
Journal:  J Histochem Cytochem       Date:  2000-04       Impact factor: 2.479

10.  An engineered multidomain bactericidal peptide as a model for targeted antibiotics against specific bacteria.

Authors:  Xiao-Qing Qiu; He Wang; Xiao-Fong Lu; Jie Zhang; Sheng-Fu Li; Gang Cheng; Lin Wan; Li Yang; Jun-Yong Zuo; Yu-Qi Zhou; Hai-Yun Wang; Xin Cheng; Su-Hua Zhang; Zheng-Rong Ou; Zi-Cheng Zhong; Jing-Qiu Cheng; You-Ping Li; George Y Wu
Journal:  Nat Biotechnol       Date:  2003-11-16       Impact factor: 54.908
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  11 in total

1.  Communication: Antimicrobial Activity of SMAP28 with a Targeting Domain for Porphyromonas gingivalis.

Authors:  Carol L Bratt; Karl G Kohlgraf; Katie Yohnke; Colleen Kummet; Deborah V Dawson; Kim A Brogden
Journal:  Probiotics Antimicrob Proteins       Date:  2010-03-01       Impact factor: 4.609

2.  Compatibility, Cytotoxicity, and Gastrointestinal Tenacity of Bacteriocin-Producing Bacteria Selected for a Consortium Probiotic Formulation to Be Used in Livestock Feed.

Authors:  Mégane Eveno; Patricia Savard; Yanath Belguesmia; Laurent Bazinet; Frédérique Gancel; Djamel Drider; Ismail Fliss
Journal:  Probiotics Antimicrob Proteins       Date:  2021-02       Impact factor: 4.609

Review 3.  Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?

Authors:  Nicole K Brogden; Kim A Brogden
Journal:  Int J Antimicrob Agents       Date:  2011-07-05       Impact factor: 5.283

4.  Targeted killing of Streptococcus mutans by a pheromone-guided "smart" antimicrobial peptide.

Authors:  Randal Eckert; Jian He; Daniel K Yarbrough; Fengxia Qi; Maxwell H Anderson; Wenyuan Shi
Journal:  Antimicrob Agents Chemother       Date:  2006-11       Impact factor: 5.191

5.  Adding selectivity to antimicrobial peptides: rational design of a multidomain peptide against Pseudomonas spp.

Authors:  Randal Eckert; Fengxia Qi; Daniel K Yarbrough; Jian He; Maxwell H Anderson; Wenyuan Shi
Journal:  Antimicrob Agents Chemother       Date:  2006-04       Impact factor: 5.191

6.  Aggregatibacter actinomycetemcomitans biofilm killing by a targeted ciprofloxacin prodrug.

Authors:  Benjamin D Reeves; Mark Young; Paul A Grieco; Peter Suci
Journal:  Biofouling       Date:  2013-08-19       Impact factor: 3.209

7.  Self-assembled DNA-THPS hydrogel as a topical antibacterial agent for wound healing.

Authors:  Xingxing Jiang; Man Li; Xiaoxi Guo; Minghui Yang; Avraham Rasooly
Journal:  ACS Appl Bio Mater       Date:  2019-02-21

8.  Targeted antimicrobial activity of a specific IgG-SMAP28 conjugate against Porphyromonas gingivalis in a mixed culture.

Authors:  Michael R Franzman; Kindra K Burnell; Farideh H Dehkordi-Vakil; Janet M Guthmiller; Deborah V Dawson; Kim A Brogden
Journal:  Int J Antimicrob Agents       Date:  2008-09-07       Impact factor: 5.283

9.  Selective activities of STAMPs against Streptococcus mutans.

Authors:  Lijun Huo; Xiangya Huang; Junqi Ling; Hongyan Liu; Jia Liu
Journal:  Exp Ther Med       Date:  2017-12-14       Impact factor: 2.447

Review 10.  Peptide and non-peptide mimetics as potential therapeutics targeting oral bacteria and oral biofilms.

Authors:  Maryta N Sztukowska; Mohammad Roky; Donald R Demuth
Journal:  Mol Oral Microbiol       Date:  2019-08-15       Impact factor: 3.563
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