| Literature DB >> 12663927 |
I T Paulsen1, L Banerjei, G S A Myers, K E Nelson, R Seshadri, T D Read, D E Fouts, J A Eisen, S R Gill, J F Heidelberg, H Tettelin, R J Dodson, L Umayam, L Brinkac, M Beanan, S Daugherty, R T DeBoy, S Durkin, J Kolonay, R Madupu, W Nelson, J Vamathevan, B Tran, J Upton, T Hansen, J Shetty, H Khouri, T Utterback, D Radune, K A Ketchum, B A Dougherty, C M Fraser.
Abstract
The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.Entities:
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Year: 2003 PMID： 12663927 DOI： 10.1126/science.1080613
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728