Literature DB >> 35005454

Self-assembled DNA-THPS hydrogel as a topical antibacterial agent for wound healing.

Xingxing Jiang1, Man Li1, Xiaoxi Guo2, Minghui Yang1, Avraham Rasooly3.   

Abstract

We report a novel and potential wound dressing hydrogel based on DNA and a green industrial microbiocide tetrakis (hydroxymethyl) phosphonium sulfate (THPS) via one-pot self-assembly. Intermolecular electrostatic interaction and hydrogen bonding between DNA and THPS together drive the formation of the adhesive DNT (DNA+THPS) hydrogel, featuring with self-healing, shear-thinning and injectability. This wound dressing hydrogel possesses broad-spectrum antibacterial ability with low cytotoxicity to L929 cells. Furthermore, the wound dressing can reduce the risk of wound infection by releasing THPS to suppress bacterial spread and accelerate wound healing. The low cost and simple preparation may make the hydrogel attractive in biomedical applications and could be a good reference to others.

Entities:  

Year:  2019        PMID： 35005454      PMCID： PMC8733899          DOI： 10.1021/acsabm.8b00818

Source DB:  PubMed          Journal:  ACS Appl Bio Mater        ISSN： 2576-6422


  40 in total

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