Literature DB >> 15726160

The application of micro reactors for organic synthesis.

Paul Watts1, Stephen J Haswell.   

Abstract

This tutorial review describes how micro reactors are being applied to synthetic chemistry covering a wide range of applications, from the preparation of nanograms of material for drug discovery and screening to the multi-tonne production of fine chemicals. This article explores how miniaturisation may revolutionise chemical synthesis and demonstrates that products are generated in higher yield and purity compared to the equivalent bulk reactions, in much shorter periods of time.

Mesh:

Substances:

Year:  2005        PMID: 15726160     DOI: 10.1039/b313866f

Source DB:  PubMed          Journal:  Chem Soc Rev        ISSN: 0306-0012            Impact factor:   54.564


  23 in total

Review 1.  Reactions in droplets in microfluidic channels.

Authors:  Helen Song; Delai L Chen; Rustem F Ismagilov
Journal:  Angew Chem Int Ed Engl       Date:  2006-11-13       Impact factor: 15.336

2.  Continuous Flow Chemistry: Reaction of Diphenyldiazomethane with p-Nitrobenzoic Acid.

Authors:  Alex Aw; Marshall Fritz; Jonathan W Napoline; Pamela Pollet; Charles L Liotta
Journal:  J Vis Exp       Date:  2017-11-15       Impact factor: 1.355

3.  Integrated Microfluidic Reactors.

Authors:  Wei-Yu Lin; Yanju Wang; Shutao Wang; Hsian-Rong Tseng
Journal:  Nano Today       Date:  2009-12       Impact factor: 20.722

4.  Development of an automated microfluidic reaction platform for multidimensional screening: reaction discovery employing bicyclo[3.2.1]octanoid scaffolds.

Authors:  John R Goodell; Jonathan P McMullen; Nikolay Zaborenko; Jason R Maloney; Chuan-Xing Ho; Klavs F Jensen; John A Porco; Aaron B Beeler
Journal:  J Org Chem       Date:  2009-08-21       Impact factor: 4.354

5.  Integrated microfluidic and imaging platform for a kinase activity radioassay to analyze minute patient cancer samples.

Authors:  Cong Fang; Yanju Wang; Nam T Vu; Wei-Yu Lin; Yao-Te Hsieh; Liudmilla Rubbi; Michael E Phelps; Markus Müschen; Yong-Mi Kim; Arion F Chatziioannou; Hsian-Rong Tseng; Thomas G Graeber
Journal:  Cancer Res       Date:  2010-09-13       Impact factor: 12.701

6.  From discovery to production: scale-out of continuous flow meso reactors.

Authors:  Peter Styring; Ana I R Parracho
Journal:  Beilstein J Org Chem       Date:  2009-06-09       Impact factor: 2.883

7.  Microfluidic radiolabeling of biomolecules with PET radiometals.

Authors:  Dexing Zeng; Amit V Desai; David Ranganathan; Tobias D Wheeler; Paul J A Kenis; David E Reichert
Journal:  Nucl Med Biol       Date:  2012-10-15       Impact factor: 2.408

8.  Polydimethylsiloxane-based conducting composites and their applications in microfluidic chip fabrication.

Authors:  Xiuqing Gong; Weijia Wen
Journal:  Biomicrofluidics       Date:  2009-03-23       Impact factor: 2.800

9.  An integrated microfluidic device for large-scale in situ click chemistry screening.

Authors:  Yanju Wang; Wei-Yu Lin; Kan Liu; Rachel J Lin; Matthias Selke; Hartmuth C Kolb; Nangang Zhang; Xing-Zhong Zhao; Michael E Phelps; Clifton K F Shen; Kym F Faull; Hsian-Rong Tseng
Journal:  Lab Chip       Date:  2009-06-17       Impact factor: 6.799

10.  Acid-mediated reactions under microfluidic conditions: a new strategy for practical synthesis of biofunctional natural products.

Authors:  Katsunori Tanaka; Koichi Fukase
Journal:  Beilstein J Org Chem       Date:  2009-08-20       Impact factor: 2.883

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.