Literature DB >> 19636457

An integrated microfluidic device for large-scale in situ click chemistry screening.

Yanju Wang1, Wei-Yu Lin, Kan Liu, Rachel J Lin, Matthias Selke, Hartmuth C Kolb, Nangang Zhang, Xing-Zhong Zhao, Michael E Phelps, Clifton K F Shen, Kym F Faull, Hsian-Rong Tseng.   

Abstract

An integrated microfluidic device has been developed to perform 1024 in situ click chemistry reactions in parallel using the bovine carbonic anhydrous II (bCAII) click chemistry system as a proof-of-concept study and a rapid hit identification approach using SPE purification and electrospray-ionization mass spectrometry, multiple reaction monitoring (MRM) analysis, all of which improves the sensitivity and throughput of the downstream analysis.

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Year:  2009        PMID： 19636457      PMCID： PMC2878189          DOI： 10.1039/b907430a

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  34 in total

Review 1.  Drug discovery by dynamic combinatorial libraries.

Authors:  Olof Ramström; Jean-Marie Lehn
Journal:  Nat Rev Drug Discov       Date:  2002-01       Impact factor: 84.694

2.  Microfluidic large-scale integration.

Authors:  Todd Thorsen; Sebastian J Maerkl; Stephen R Quake
Journal:  Science       Date:  2002-09-26       Impact factor: 47.728

3.  Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays.

Authors:  Bo Zheng; Joshua D Tice; Rustem F Ismagilov
Journal:  Anal Chem       Date:  2004-09-01       Impact factor: 6.986

4.  Proteomic profiling of metalloprotease activities with cocktails of active-site probes.

Authors:  Stephan A Sieber; Sherry Niessen; Heather S Hoover; Benjamin F Cravatt
Journal:  Nat Chem Biol       Date:  2006-03-26       Impact factor: 15.040

Review 5.  Control and detection of chemical reactions in microfluidic systems.

Authors:  Andrew J DeMello
Journal:  Nature       Date:  2006-07-27       Impact factor: 49.962

6.  Inhibitors of HIV-1 protease by using in situ click chemistry.

Authors:  Matthew Whiting; John Muldoon; Ying-Chuan Lin; Steven M Silverman; William Lindstrom; Arthur J Olson; Hartmuth C Kolb; M G Finn; K Barry Sharpless; John H Elder; Valery V Fokin
Journal:  Angew Chem Int Ed Engl       Date:  2006-02-20       Impact factor: 15.336

7.  Counting low-copy number proteins in a single cell.

Authors:  Bo Huang; Hongkai Wu; Devaki Bhaya; Arthur Grossman; Sebastien Granier; Brian K Kobilka; Richard N Zare
Journal:  Science       Date:  2007-01-05       Impact factor: 47.728

8.  Multiphase organic synthesis in microchannel reactors.

Authors:  Juta Kobayashi; Yuichiro Mori; Shū Kobayashi
Journal:  Chem Asian J       Date:  2006-07-17

9.  Bcl-XL-templated assembly of its own protein-protein interaction modulator from fragments decorated with thio acids and sulfonyl azides.

Authors:  Xiangdong Hu; Jiazhi Sun; Hong-Gang Wang; Roman Manetsch
Journal:  J Am Chem Soc       Date:  2008-09-24       Impact factor: 15.419

10.  A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanides.

Authors:  Zachary P Demko; K Barry Sharpless
Journal:  Angew Chem Int Ed Engl       Date:  2002-06-17       Impact factor: 15.336
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  24 in total

Review 1.  Microfluidics for positron emission tomography probe development.

Authors:  Ming-Wei Wang; Wei-Yu Lin; Kan Liu; Michael Masterman-Smith; Clifton Kwang-Fu Shen
Journal:  Mol Imaging       Date:  2010-08       Impact factor: 4.488

2.  Pneumatic oscillator circuits for timing and control of integrated microfluidics.

Authors:  Philip N Duncan; Transon V Nguyen; Elliot E Hui
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-21       Impact factor: 11.205

3.  Microfabricated Systems and Assays for Studying the Cytoskeletal Organization, Micromechanics, and Motility Patterns of Cancerous Cells.

Authors:  Sabil Huda; Didzis Pilans; Monika Makurath; Thomas Hermans; Kristiana Kandere-Grzybowska; Bartosz A Grzybowski
Journal:  Adv Mater Interfaces       Date:  2014-08-28       Impact factor: 6.147

4.  Chip in a lab: Microfluidics for next generation life science research.

Authors:  Aaron M Streets; Yanyi Huang
Journal:  Biomicrofluidics       Date:  2013-01-31       Impact factor: 2.800

Review 5.  Automating drug discovery.

Authors:  Gisbert Schneider
Journal:  Nat Rev Drug Discov       Date:  2017-12-15       Impact factor: 84.694

6.  Cell-Based Kinetic Target-Guided Synthesis of an Enzyme Inhibitor.

Authors:  Henrik Antti; Magnus Sellstedt
Journal:  ACS Med Chem Lett       Date:  2018-03-08       Impact factor: 4.345

7.  Molecular Imaging Probe Development using Microfluidics.

Authors:  Kan Liu; Ming-Wei Wang; Wei-Yu Lin; Duy Linh Phung; Mark D Girgis; Anna M Wu; James S Tomlinson; Clifton K-F Shen
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

8.  Integrated Microfluidic Reactors.

Authors:  Wei-Yu Lin; Yanju Wang; Shutao Wang; Hsian-Rong Tseng
Journal:  Nano Today       Date:  2009-12       Impact factor: 20.722

9.  Delivery of intact transcription factor by using self-assembled supramolecular nanoparticles.

Authors:  Yang Liu; Hao Wang; Ken-ichiro Kamei; Ming Yan; Kuan-Ju Chen; Qinghua Yuan; Linqi Shi; Yunfeng Lu; Hsian-Rong Tseng
Journal:  Angew Chem Int Ed Engl       Date:  2011-03-02       Impact factor: 15.336

10.  Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor.

Authors:  Tomoyasu Hirose; Nobuo Maita; Hiroaki Gouda; Jun Koseki; Tsuyoshi Yamamoto; Akihiro Sugawara; Hirofumi Nakano; Shuichi Hirono; Kazuro Shiomi; Takeshi Watanabe; Hisaaki Taniguchi; K Barry Sharpless; Satoshi Omura; Toshiaki Sunazuka
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205
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