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Literature DB >> 15654076

Silencing near tRNA genes requires nucleolar localization.

Li Wang¹, Rebecca A Haeusler, Paul D Good, Martin Thompson, Sapna Nagar, David R Engelke.

Abstract

Transcription by RNA polymerase II is antagonized by the presence of a nearby tRNA gene in Saccharomyces cerevisiae. To test hypotheses concerning the mechanism of this tRNA gene-mediated (tgm) silencing, the effects of specific gene deletions were determined. The results show that the mechanism of silencing near tRNA genes is fundamentally different from other forms of transcriptional silencing in yeast. Rather, tgm silencing is dependent on the ability to cluster the dispersed tRNA genes in or near the nucleolus, constituting a form of three-dimensional gene control.

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Year: 2005 PMID： 15654076 PMCID： PMC3761214 DOI： 10.1074/jbc.C500017200

Source DB: PubMed Journal: J Biol Chem ISSN： 0021-9258 Impact factor: 5.157

25 in total

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Authors: P Heun; T Laroche; K Shimada; P Furrer; S M Gasser
Journal: Science Date: 2001-12-07 Impact factor: 47.728

Review 2. Visualizing chromatin dynamics in interphase nuclei.

Authors: Susan M Gasser
Journal: Science Date: 2002-05-24 Impact factor: 47.728

3. Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism.

Authors: Mary Bryk; Scott D Briggs; Brian D Strahl; M Joan Curcio; C David Allis; Fred Winston
Journal: Curr Biol Date: 2002-01-22 Impact factor: 10.834

Review 4. Transcriptional silencing in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

Authors: Ying Huang
Journal: Nucleic Acids Res Date: 2002-04-01 Impact factor: 16.971

5. A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.

Authors: J S Smith; E Caputo; J D Boeke
Journal: Mol Cell Biol Date: 1999-04 Impact factor: 4.272

6. Transcription factor UAF, expansion and contraction of ribosomal DNA (rDNA) repeats, and RNA polymerase switch in transcription of yeast rDNA.

Authors: M Oakes; I Siddiqi; L Vu; J Aris; M Nomura
Journal: Mol Cell Biol Date: 1999-12 Impact factor: 4.272

7. Transcription of chromosomal rRNA genes by both RNA polymerase I and II in yeast uaf30 mutants lacking the 30 kDa subunit of transcription factor UAF.

Authors: I N Siddiqi; J A Dodd; L Vu; K Eliason; M L Oakes; J Keener; R Moore; M K Young; M Nomura
Journal: EMBO J Date: 2001-08-15 Impact factor: 11.598

8. Silencing in yeast rDNA chromatin: reciprocal relationship in gene expression between RNA polymerase I and II.

Authors: Francesco Cioci; Loan Vu; Kristilyn Eliason; Melanie Oakes; Imran N Siddiqi; Masayasu Nomura
Journal: Mol Cell Date: 2003-07 Impact factor: 17.970

Review 9. Mammalian retroelements.

Authors: Prescott L Deininger; Mark A Batzer
Journal: Genome Res Date: 2002-10 Impact factor: 9.043

10. Transcriptional interactions between yeast tRNA genes, flanking genes and Ty elements: a genomic point of view.

Authors: Eric C Bolton; Jef D Boeke
Journal: Genome Res Date: 2003-02 Impact factor: 9.043

41 in total

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Authors: Eric M Phizicky; Anita K Hopper
Journal: Genes Dev Date: 2010-09-01 Impact factor: 11.361

Review 2. The budding yeast nucleus.

Authors: Angela Taddei; Heiko Schober; Susan M Gasser
Journal: Cold Spring Harb Perspect Biol Date: 2010-06-16 Impact factor: 10.005

3. RNA polymerase II (RNAP II)-associated factors are recruited to tRNA loci, revealing that RNAP II- and RNAP III-mediated transcriptions overlap in yeast.

Authors: Edoardo Trotta
Journal: J Biol Chem Date: 2019-06-24 Impact factor: 5.157

4. Yeast nuclear RNA processing.

Authors: Jade Bernstein; Eric A Toth
Journal: World J Biol Chem Date: 2012-01-26

5. Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing.

Authors: Matthew Pratt-Hyatt; Dave A Pai; Rebecca A Haeusler; Glenn G Wozniak; Paul D Good; Erin L Miller; Ian X McLeod; John R Yates; Anita K Hopper; David R Engelke
Journal: Proc Natl Acad Sci U S A Date: 2013-07-29 Impact factor: 11.205

Review 6. The cytoplasmic and nuclear populations of the eukaryote tRNA-isopentenyl transferase have distinct functions with implications in human cancer.

Authors: P J Smaldino; D F Read; M Pratt-Hyatt; A K Hopper; D R Engelke
Journal: Gene Date: 2014-09-26 Impact factor: 3.688

7. A sequence-specific interaction between the Saccharomyces cerevisiae rRNA gene repeats and a locus encoding an RNA polymerase I subunit affects ribosomal DNA stability.

Authors: Inswasti Cahyani; Andrew G Cridge; David R Engelke; Austen R D Ganley; Justin M O'Sullivan
Journal: Mol Cell Biol Date: 2014-11-24 Impact factor: 4.272