Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected.

Literature DB >> 15611159

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected.

Abstract

We performed a 1012-generation mutation-accumulation (MA) experiment in the yeast, Saccharomyces cerevisiae. The MA lines exhibited a significant reduction in mean fitness and a significant increase in variance in fitness. We found that 5.75% of the fitness-altering mutations accumulated were beneficial. This finding contradicts the widely held belief that nearly all fitness-altering mutations are deleterious. The mutation rate was estimated as 6.3 x 10(-5) mutations per haploid genome per generation and the average heterozygous fitness effect of a mutation as 0.061. These estimates are compatible with previous estimates in yeast.

Entities: Disease Species

Mesh：

Year: 2004 PMID： 15611159 PMCID： PMC1448740 DOI： 10.1534/genetics.104.033761

Source DB: PubMed Journal: Genetics ISSN： 0016-6731 Impact factor: 4.562

40 in total

Spontaneous mutations in diploid Saccharomyces cerevisiae: more beneficial than expected.

1. Haldane's sieve and adaptation from the standing genetic variation.

Review 2. Estimation of spontaneous genome-wide mutation rate parameters: whither beneficial mutations?

3. Adaptation and the cost of complexity.

4. Quantifying the slightly deleterious mutation model of molecular evolution.

5. EMS-induced polygenic mutation rates for nine quantitative characters in Drosophila melanogaster.

6. Spontaneous deleterious mutation in Arabidopsis thaliana.

Review 7. Mutations affecting fitness in Drosophila populations.

8. Estimates of the rate and distribution of fitness effects of spontaneous mutation in Saccharomyces cerevisiae.

9. Estimate of the genomic mutation rate deleterious to overall fitness in E. coli.

10. The distribution of mutation effects on viability in Drosophila melanogaster.

Review 1. Beneficial mutations and the dynamics of adaptation in asexual populations.

2. Gene action of new mutations in Arabidopsis thaliana.

3. Experimental estimate of the abundance and effects of nearly neutral mutations in the RNA virus phi 6.

4. The speed of evolution and maintenance of variation in asexual populations.

5. Sulfur isotope fractionation during the evolutionary adaptation of a sulfate-reducing bacterium.

6. Beneficial mutation selection balance and the effect of linkage on positive selection.

Review 7. Analysis and implications of mutational variation.

8. Genomic mutation rates that neutralize adaptive evolution and natural selection.

9. Clonal interference, multiple mutations and adaptation in large asexual populations.

10. Rapid increase in viability due to new beneficial mutations in Drosophila melanogaster.