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Literature DB >> 15574514

A pre-tRNA carrying intron features typical of Archaea is spliced in yeast.

Gianfranco Di Segni¹, Lodovica Borghese, Silvia Sebastiani, Glauco P Tocchini-Valentini.

Abstract

Archaeal pre-tRNAs are characterized by the presence of the bulge-helix-bulge (BHB) structure in the intron stem-and-loop region. A chimeric pre-tRNA was constructed bearing an intron of the archaeal type and the mature domain of the Saccharomyces cerevisiae suppressor SUP4 tRNA(Tyr). This pre-tRNA(ArchEuka) is correctly cleaved in several cell-free extracts and by purified splicing endonucleases. It is also cleaved and ligated in S. cerevisiae cells, providing efficient suppression of nonsense mutations in various genes.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2004 PMID： 15574514 PMCID： PMC1370692 DOI： 10.1261/rna.7138805

Source DB: PubMed Journal: RNA ISSN： 1355-8382 Impact factor: 4.942

31 in total

1. Cleavage of non-tRNA substrates by eukaryal tRNA splicing endonucleases.

Authors: P Fruscoloni; M I Baldi; G P Tocchini-Valentini
Journal: EMBO Rep Date: 2001-03 Impact factor: 8.807

2. Crystal structure of a dimeric archaeal splicing endonuclease.

Authors: H Li; J Abelson
Journal: J Mol Biol Date: 2000-09-22 Impact factor: 5.469

3. The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.

Authors: C R Trotta; F Miao; E A Arn; S W Stevens; C K Ho; R Rauhut; J N Abelson
Journal: Cell Date: 1997-06-13 Impact factor: 41.582

4. Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif.

Authors: J L Diener; P B Moore
Journal: Mol Cell Date: 1998-05 Impact factor: 17.970

5. Transcription and excision of a large intron in the tRNATrp gene of an archaebacterium, Halobacterium volcanii.

Authors: C J Daniels; R Gupta; W F Doolittle
Journal: J Biol Chem Date: 1985-03-10 Impact factor: 5.157

6. Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae.

Authors: S Sarkar; A K Azad; A K Hopper
Journal: Proc Natl Acad Sci U S A Date: 1999-12-07 Impact factor: 11.205

7. Lineage-specific loss and divergence of functionally linked genes in eukaryotes.

Authors: L Aravind; H Watanabe; D J Lipman; E V Koonin
Journal: Proc Natl Acad Sci U S A Date: 2000-10-10 Impact factor: 11.205

8. The genome sequence of Schizosaccharomyces pombe.

Authors: V Wood; R Gwilliam; M-A Rajandream; M Lyne; R Lyne; A Stewart; J Sgouros; N Peat; J Hayles; S Baker; D Basham; S Bowman; K Brooks; D Brown; S Brown; T Chillingworth; C Churcher; M Collins; R Connor; A Cronin; P Davis; T Feltwell; A Fraser; S Gentles; A Goble; N Hamlin; D Harris; J Hidalgo; G Hodgson; S Holroyd; T Hornsby; S Howarth; E J Huckle; S Hunt; K Jagels; K James; L Jones; M Jones; S Leather; S McDonald; J McLean; P Mooney; S Moule; K Mungall; L Murphy; D Niblett; C Odell; K Oliver; S O'Neil; D Pearson; M A Quail; E Rabbinowitsch; K Rutherford; S Rutter; D Saunders; K Seeger; S Sharp; J Skelton; M Simmonds; R Squares; S Squares; K Stevens; K Taylor; R G Taylor; A Tivey; S Walsh; T Warren; S Whitehead; J Woodward; G Volckaert; R Aert; J Robben; B Grymonprez; I Weltjens; E Vanstreels; M Rieger; M Schäfer; S Müller-Auer; C Gabel; M Fuchs; A Düsterhöft; C Fritzc; E Holzer; D Moestl; H Hilbert; K Borzym; I Langer; A Beck; H Lehrach; R Reinhardt; T M Pohl; P Eger; W Zimmermann; H Wedler; R Wambutt; B Purnelle; A Goffeau; E Cadieu; S Dréano; S Gloux; V Lelaure; S Mottier; F Galibert; S J Aves; Z Xiang; C Hunt; K Moore; S M Hurst; M Lucas; M Rochet; C Gaillardin; V A Tallada; A Garzon; G Thode; R R Daga; L Cruzado; J Jimenez; M Sánchez; F del Rey; J Benito; A Domínguez; J L Revuelta; S Moreno; J Armstrong; S L Forsburg; L Cerutti; T Lowe; W R McCombie; I Paulsen; J Potashkin; G V Shpakovski; D Ussery; B G Barrell; P Nurse; L Cerrutti
Journal: Nature Date: 2002-02-21 Impact factor: 49.962

9. An archaeal endoribonuclease catalyzes cis- and trans- nonspliceosomal splicing in mouse cells.

Authors: Giancarlo Deidda; Nicoletta Rossi; Glauco P Tocchini-Valentini
Journal: Nat Biotechnol Date: 2003-11-02 Impact factor: 54.908

10. Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease.

Authors: D G Attardi; I Margarit; G P Tocchini-Valentini
Journal: EMBO J Date: 1985-12-01 Impact factor: 11.598

7 in total

A pre-tRNA carrying intron features typical of Archaea is spliced in yeast.

1. Cleavage of non-tRNA substrates by eukaryal tRNA splicing endonucleases.

2. Crystal structure of a dimeric archaeal splicing endonuclease.

3. The yeast tRNA splicing endonuclease: a tetrameric enzyme with two active site subunits homologous to the archaeal tRNA endonucleases.

4. Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif.

5. Transcription and excision of a large intron in the tRNATrp gene of an archaebacterium, Halobacterium volcanii.

6. Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae.

7. Lineage-specific loss and divergence of functionally linked genes in eukaryotes.

8. The genome sequence of Schizosaccharomyces pombe.

9. An archaeal endoribonuclease catalyzes cis- and trans- nonspliceosomal splicing in mouse cells.

10. Structural alterations in mutant precursors of the yeast tRNALeu3 gene which behave as defective substrates for a highly purified splicing endoribonuclease.

1. Transfer RNA genes in pieces.

2. Long-distance splicing.

3. Splicing of mRNA mediated by tRNA sequences in mouse cells.

Review 4. Transfer RNA processing in archaea: unusual pathways and enzymes.

5. Engineering and expressing circular RNAs via tRNA splicing.

6. Cis- and trans-splicing of mRNAs mediated by tRNA sequences in eukaryotic cells.

Review 7. Handling tRNA introns, archaeal way and eukaryotic way.