Literature DB >> 10588711

Nuclear tRNA aminoacylation and its role in nuclear export of endogenous tRNAs in Saccharomyces cerevisiae.

S Sarkar1, A K Azad, A K Hopper.   

Abstract

Nuclear tRNA aminoacylation was proposed to provide a proofreading step in Xenopus oocytes, ensuring nuclear export of functional tRNAs [Lund, E. & Dahlberg, J. E. (1998) Science 282, 2082-2085]. Herein, it is documented that tRNA aminoacylation also occurs in yeast nuclei and is important for tRNA export. We propose that tRNA aminoacylation functions in one of at least two parallel paths of tRNA export in yeast. Alteration of one aminoacyl-tRNA synthetase affects export of only cognate tRNA, whereas alterations of two other aminoacyl-tRNA synthetases affect export of both cognate and noncognate tRNAs. Saturation of tRNA export pathway is a possible explanation of this phenomenon.

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Year:  1999        PMID： 10588711      PMCID： PMC24442          DOI： 10.1073/pnas.96.25.14366

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  35 in total

1.  Coordination of tRNA nuclear export with processing of tRNA.

Authors:  G Lipowsky; F R Bischoff; E Izaurralde; U Kutay; S Schäfer; H J Gross; H Beier; D Görlich
Journal:  RNA       Date:  1999-04       Impact factor: 4.942

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Authors:  G Keith; J Gangloff; G Dirheimer
Journal:  Biochimie       Date:  1971       Impact factor: 4.079

3.  A mutant of yeast with a defective methionyl-tRNA synthetase.

Authors:  C S McLaughlin; L H Hartwell
Journal:  Genetics       Date:  1969-03       Impact factor: 4.562

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Authors:  L H Hartwell; C S McLaughlin
Journal:  Proc Natl Acad Sci U S A       Date:  1968-02       Impact factor: 11.205

5.  A mutant of yeast apparently defective in the initiation of protein synthesis.

Authors:  L H Hartwell; C S McLaughlin
Journal:  Proc Natl Acad Sci U S A       Date:  1969-02       Impact factor: 11.205

6.  The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.

Authors:  G Simos; A Segref; F Fasiolo; K Hellmuth; A Shevchenko; M Mann; E C Hurt
Journal:  EMBO J       Date:  1996-10-01       Impact factor: 11.598

7.  The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals.

Authors:  P Kerjan; C Cerini; M Sémériva; M Mirande
Journal:  Biochim Biophys Acta       Date:  1994-04-21

8.  Relation between aminoacyl-tRNA stability and the fixed amino acid.

Authors:  D Hentzen; P Mandel; J P Garel
Journal:  Biochim Biophys Acta       Date:  1972-10-11

9.  Transfer RNA gene redundancy and translational selection in Saccharomyces cerevisiae.

Authors:  R Percudani; A Pavesi; S Ottonello
Journal:  J Mol Biol       Date:  1997-05-02       Impact factor: 5.469

10.  Mechanisms leading to and the consequences of altering the normal distribution of ATP(CTP):tRNA nucleotidyltransferase in yeast.

Authors:  C L Wolfe; A K Hopper; N C Martin
Journal:  J Biol Chem       Date:  1996-03-01       Impact factor: 5.157
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  73 in total

1.  Aminoacyl-tRNA synthetases database.

Authors:  M Szymanski; M A Deniziak; J Barciszewski
Journal:  Nucleic Acids Res       Date:  2001-01-01       Impact factor: 16.971

Review 2.  Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.

Authors:  R J Maraia; R V Intine
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

3.  ADEPTs: information necessary for subcellular distribution of eukaryotic sorting isozymes resides in domains missing from eubacterial and archaeal counterparts.

Authors:  D R Stanford; N C Martin; A K Hopper
Journal:  Nucleic Acids Res       Date:  2000-01-15       Impact factor: 16.971

4.  Defects in tRNA processing and nuclear export induce GCN4 translation independently of phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.

Authors:  H Qiu; C Hu; J Anderson; G R Björk; S Sarkar; A K Hopper; A G Hinnebusch
Journal:  Mol Cell Biol       Date:  2000-04       Impact factor: 4.272

Review 5.  Nuclear RNA export pathways.

Authors:  B R Cullen
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

6.  The intracellular location of two aminoacyl-tRNA synthetases depends on complex formation with Arc1p.

Authors:  K Galani; H Grosshans; K Deinert; E C Hurt; G Simos
Journal:  EMBO J       Date:  2001-12-03       Impact factor: 11.598

7.  A nuclear AAA-type ATPase (Rix7p) is required for biogenesis and nuclear export of 60S ribosomal subunits.

Authors:  O Gadal; D Strauss; J Braspenning; D Hoepfner; E Petfalski; P Philippsen; D Tollervey; E Hurt
Journal:  EMBO J       Date:  2001-07-16       Impact factor: 11.598

8.  Role of nuclear pools of aminoacyl-tRNA synthetases in tRNA nuclear export.

Authors:  A K Azad; D R Stanford; S Sarkar; A K Hopper
Journal:  Mol Biol Cell       Date:  2001-05       Impact factor: 4.138

Review 9.  The renaissance of aminoacyl-tRNA synthesis.

Authors:  M Ibba; D Söll
Journal:  EMBO Rep       Date:  2001-05       Impact factor: 8.807

10.  A pre-tRNA carrying intron features typical of Archaea is spliced in yeast.

Authors:  Gianfranco Di Segni; Lodovica Borghese; Silvia Sebastiani; Glauco P Tocchini-Valentini
Journal:  RNA       Date:  2004-12-01       Impact factor: 4.942
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