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Literature DB >> 15479633

Spatial positioning; a new dimension in genome function.

Abstract

The eukaryotic cell nucleus is a heterogeneous organelle. Chromosomes are nonrandomly positioned within the nuclear space, and individual gene loci experience distinct local environments due to the presence of chromatin domains and subnuclear compartments. Recent observations have highlighted the important yet still largely mysterious role of spatial positioning in genome activity and stability.

Mesh：

Year: 2004 PMID： 15479633 DOI： 10.1016/j.cell.2004.09.035

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

71 in total

Review 1. Chromosomal translocations and palindromic AT-rich repeats.

Authors: Takema Kato; Hiroki Kurahashi; Beverly S Emanuel
Journal: Curr Opin Genet Dev Date: 2012-03-06 Impact factor: 5.578

2. Twenty-four chromosome FISH in human IVF embryos reveals patterns of post-zygotic chromosome segregation and nuclear organisation.

Authors: D Ioannou; K G L Fonseka; E J Meershoek; A R Thornhill; A Abogrein; M Ellis; D K Griffin
Journal: Chromosome Res Date: 2012-06-29 Impact factor: 5.239

Review 3. Higher-order genome organization in human disease.

Authors: Tom Misteli
Journal: Cold Spring Harb Perspect Biol Date: 2010-06-30 Impact factor: 10.005

4. SUPPRESSOR OF FRIGIDA3 encodes a nuclear ACTIN-RELATED PROTEIN6 required for floral repression in Arabidopsis.

Authors: Kyuha Choi; Sanghee Kim; Sang Yeol Kim; Minsoo Kim; Youbong Hyun; Horim Lee; Sunghwa Choe; Sang-Gu Kim; Scott Michaels; Ilha Lee
Journal: Plant Cell Date: 2005-09-09 Impact factor: 11.277

5. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures.

Authors: Kris Noel Dahl; Adam J Engler; J David Pajerowski; Dennis E Discher
Journal: Biophys J Date: 2005-07-29 Impact factor: 4.033

Review 6. Chromatin physics: Replacing multiple, representation-centered descriptions at discrete scales by a continuous, function-dependent self-scaled model.

Authors: C Lavelle; A Benecke
Journal: Eur Phys J E Soft Matter Date: 2006-02-22 Impact factor: 1.890

Spatial positioning; a new dimension in genome function.

Review 1. Chromosomal translocations and palindromic AT-rich repeats.

2. Twenty-four chromosome FISH in human IVF embryos reveals patterns of post-zygotic chromosome segregation and nuclear organisation.

Review 3. Higher-order genome organization in human disease.

4. SUPPRESSOR OF FRIGIDA3 encodes a nuclear ACTIN-RELATED PROTEIN6 required for floral repression in Arabidopsis.

5. Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures.

Review 6. Chromatin physics: Replacing multiple, representation-centered descriptions at discrete scales by a continuous, function-dependent self-scaled model.

7. PIAS1 confers DNA-binding specificity on the Msx1 homeoprotein.

Review 8. Nuclear organization mediates cancer-compromised genetic and epigenetic control.

Review 9. Nuclear microenvironment in cancer diagnosis and treatment.

10. The meaning of gene positioning.