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Literature DB >> 17477352

Nuclear microenvironment in cancer diagnosis and treatment.

Abstract

The nuclear architecture plays an important role in the temporal and spatial control of complex functional processes within the nucleus. Alterations in nuclear structures are characteristic of cancer cells and the mechanisms underlying these perturbations may directly contribute to tumor development and progression. In this review, we will highlight aspects of the nuclear microenvironment that are perturbed during tumorigenesis and discuss how a greater understanding of the role of nuclear structure in the control of gene expression can provide new options for cancer diagnosis and treatment.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2008 PMID： 17477352 PMCID： PMC3098524 DOI： 10.1002/jcb.21353

Source DB: PubMed Journal: J Cell Biochem ISSN： 0730-2312 Impact factor: 4.429

69 in total

Review 1. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.

Authors: A Melnick; J D Licht
Journal: Blood Date: 1999-05-15 Impact factor: 22.113

Review 2. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.

Authors: Christian Lanctôt; Thierry Cheutin; Marion Cremer; Giacomo Cavalli; Thomas Cremer
Journal: Nat Rev Genet Date: 2007-02 Impact factor: 53.242

Review 3. Beyond the sequence: cellular organization of genome function.

Authors: Tom Misteli
Journal: Cell Date: 2007-02-23 Impact factor: 41.582

4. A CK2-dependent mechanism for degradation of the PML tumor suppressor.

Authors: Pier Paolo Scaglioni; Thomas M Yung; Lu Fan Cai; Hediye Erdjument-Bromage; Andrew J Kaufman; Bhuvanesh Singh; Julie Teruya-Feldstein; Paul Tempst; Pier Paolo Pandolfi
Journal: Cell Date: 2006-07-28 Impact factor: 41.582

5. CK2 and PML: regulating the regulator.

Authors: Valérie Lallemand-Breitenbach; Hugues de Thé
Journal: Cell Date: 2006-07-28 Impact factor: 41.582

6. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

Authors: Brunangelo Falini; Cristina Mecucci; Enrico Tiacci; Myriam Alcalay; Roberto Rosati; Laura Pasqualucci; Roberta La Starza; Daniela Diverio; Emanuela Colombo; Antonella Santucci; Barbara Bigerna; Roberta Pacini; Alessandra Pucciarini; Arcangelo Liso; Marco Vignetti; Paola Fazi; Natalia Meani; Valentina Pettirossi; Giuseppe Saglio; Franco Mandelli; Francesco Lo-Coco; Pier-Giuseppe Pelicci; Massimo F Martelli
Journal: N Engl J Med Date: 2005-01-20 Impact factor: 91.245

2. Wide-scale alterations in interchromosomal organization in breast cancer cells: defining a network of interacting chromosomes.

Authors: Andrew J Fritz; Branislav Stojkovic; Hu Ding; Jinhui Xu; Sambit Bhattacharya; Daniel Gaile; Ronald Berezney
Journal: Hum Mol Genet Date: 2014-05-15 Impact factor: 6.150

2 in total

Nuclear microenvironment in cancer diagnosis and treatment.

Review 1. Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia.

Review 2. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions.

Review 3. Beyond the sequence: cellular organization of genome function.

4. A CK2-dependent mechanism for degradation of the PML tumor suppressor.

5. CK2 and PML: regulating the regulator.

6. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.

Review 7. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.

8. p300 modulates nuclear morphology in prostate cancer.

9. PML is essential for multiple apoptotic pathways.

10. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor.

Review 1. Nuclear morphometry, nucleomics and prostate cancer progression.

2. Wide-scale alterations in interchromosomal organization in breast cancer cells: defining a network of interacting chromosomes.