Literature DB >> 15372090

Pharmacogenetics: ethical problems and solutions.

Alasdair Breckenridge1, Klaus Lindpaintner, Peter Lipton, Howard McLeod, Mark Rothstein, Helen Wallace.   

Abstract

Regulators, drug companies, academic scientists, bioethicists, clinicians and, increasingly, the general public are starting to realize that pharmacogenetics (PGx) will probably have a huge impact on the way in which we treat both common and rare diseases. But how much thought has gone into the ethical issues that the incorportation of phamacogenetic testing into drug discovery, prescription and use will entail? It seems that "quite a bit" is the answer, as the diverse viewpoints of representatives of all of these groups presented here illustrate. However, these views also highlight that now is the time to start formulating and implementing solutions to these potential problems.

Keywords:  Genetics and Reproduction

Mesh:

Year:  2004        PMID: 15372090     DOI: 10.1038/nrg1431

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  6 in total

Review 1.  Pharmacogenomics: challenges and opportunities.

Authors:  Dan M Roden; Russ B Altman; Neal L Benowitz; David A Flockhart; Kathleen M Giacomini; Julie A Johnson; Ronald M Krauss; Howard L McLeod; Mark J Ratain; Mary V Relling; Huijun Z Ring; Alan R Shuldiner; Richard M Weinshilboum; Scott T Weiss
Journal:  Ann Intern Med       Date:  2006-11-21       Impact factor: 25.391

Review 2.  Educational and social-ethical issues in the pursuit of molecular medicine.

Authors:  Panagiotis A Konstantinopoulos; Michalis V Karamouzis; Athanasios G Papavassiliou
Journal:  Mol Med       Date:  2008-12-10       Impact factor: 6.354

Review 3.  Genetic diversity and new therapeutic concepts.

Authors:  Barkur S Shastry
Journal:  J Hum Genet       Date:  2005-07-23       Impact factor: 3.172

Review 4.  Genome sequencing in the clinic: the past, present, and future of genomic medicine.

Authors:  Jeremy W Prokop; Thomas May; Kim Strong; Stephanie M Bilinovich; Caleb Bupp; Surender Rajasekaran; Elizabeth A Worthey; Jozef Lazar
Journal:  Physiol Genomics       Date:  2018-05-04       Impact factor: 3.107

Review 5.  Attitudes of health care professionals toward pharmacogenetic testing.

Authors:  Nathalie K Zgheib; Thalia Arawi; Rami A Mahfouz; Ramzi Sabra
Journal:  Mol Diagn Ther       Date:  2011-04-01       Impact factor: 4.074

6.  Positive perception of pharmacogenetic testing for psychotropic medications.

Authors:  Matthew B Lanktree; Gwyneth Zai; Laura E Vanderbeek; Daniel E Giuffra; David S Smithson; Lucas B Kipp; Timothy R Dalseg; Mark Speechley; James L Kennedy
Journal:  Hum Psychopharmacol       Date:  2014-03-07       Impact factor: 1.672

  6 in total

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