Literature DB >> 19043478

Educational and social-ethical issues in the pursuit of molecular medicine.

Panagiotis A Konstantinopoulos1, Michalis V Karamouzis, Athanasios G Papavassiliou.   

Abstract

Molecular medicine is transforming everyday clinical practice from an empirical art to a rational ortho-molecular science. The prevailing concept in this emerging framework of molecular medicine is a personalized approach to disease prevention, diagnosis, prognosis, and treatment. In this mini-review, we discuss the educational and social-ethical issues raised by the advances of biomedical research as related to medical practice; outline the implications of molecular medicine for patients, physicians, and researchers; and underline the responsibilities of academia and the pharmaceutical industry to translate the scientific knowledge to a meaningful improvement of the quality of life across all members of society.

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Year:  2008        PMID： 19043478      PMCID： PMC2588413          DOI： 10.2119/molmed.2008.00120

Source DB:  PubMed          Journal:  Mol Med        ISSN： 1076-1551            Impact factor:   6.354


  16 in total

1.  Clinical practice in the new era. A fusion of molecular biology and classical medicine is transforming the way we look at and treat diseases.

Authors:  A G Papavassiliou
Journal:  EMBO Rep       Date:  2001-02       Impact factor: 8.807

2.  Integrating molecular medicine into the medical school curriculum.

Authors:  H C Smith; E M Hundert
Journal:  Mol Med Today       Date:  1999-03

3.  Careers in translational clinical research-historical perspectives, future challenges.

Authors:  David G Nathan
Journal:  JAMA       Date:  2002-05-08       Impact factor: 56.272

Review 4.  Pharmacogenetics: ethical problems and solutions.

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Review 5.  The concept of synthetic lethality in the context of anticancer therapy.

Authors:  William G Kaelin
Journal:  Nat Rev Cancer       Date:  2005-09       Impact factor: 60.716

Review 6.  Microarray analysis and tumor classification.

Authors:  John Quackenbush
Journal:  N Engl J Med       Date:  2006-06-08       Impact factor: 91.245

7.  Addressing the needs of basic and clinical research: analysis of graduates of the University of Pennsylvania MD-PhD program.

Authors:  P Schwartz; G N Gaulton
Journal:  JAMA       Date:  1999-01-06       Impact factor: 56.272

8.  A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer.

Authors:  Soonmyung Paik; Steven Shak; Gong Tang; Chungyeul Kim; Joffre Baker; Maureen Cronin; Frederick L Baehner; Michael G Walker; Drew Watson; Taesung Park; William Hiller; Edwin R Fisher; D Lawrence Wickerham; John Bryant; Norman Wolmark
Journal:  N Engl J Med       Date:  2004-12-10       Impact factor: 91.245

Review 9.  Epidermal growth factor receptor mutations in lung cancer.

Authors:  Sreenath V Sharma; Daphne W Bell; Jeffrey Settleman; Daniel A Haber
Journal:  Nat Rev Cancer       Date:  2007-03       Impact factor: 60.716

10.  Core signaling pathways in human pancreatic cancers revealed by global genomic analyses.

Authors:  Siân Jones; Xiaosong Zhang; D Williams Parsons; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; Hirohiko Kamiyama; Antonio Jimeno; Seung-Mo Hong; Baojin Fu; Ming-Tseh Lin; Eric S Calhoun; Mihoko Kamiyama; Kimberly Walter; Tatiana Nikolskaya; Yuri Nikolsky; James Hartigan; Douglas R Smith; Manuel Hidalgo; Steven D Leach; Alison P Klein; Elizabeth M Jaffee; Michael Goggins; Anirban Maitra; Christine Iacobuzio-Donahue; James R Eshleman; Scott E Kern; Ralph H Hruban; Rachel Karchin; Nickolas Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728
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  1 in total

1.  From art to science: a new epistemological status for medicine? On expectations regarding personalized medicine.

Authors:  Urban Wiesing
Journal:  Med Health Care Philos       Date:  2018-12
  1 in total

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