| Literature DB >> 15324904 |
Linda L Brockunier1, Jiafang He, Lawrence F Colwell, Bahanu Habulihaz, Huaibing He, Barbara Leiting, Kathryn A Lyons, Frank Marsilio, Reshma A Patel, Yohannes Teffera, Joseph K Wu, Nancy A Thornberry, Ann E Weber, Emma R Parmee.
Abstract
Incorporation of a fluorophenyl beta-amino amide moiety into piperazine screening lead 2 has resulted in the discovery of a structurally novel series of potent and selective DP-IV inhibitors. Simplification of the molecule and incorporation of multiple fluorine atoms on the phenyl ring has provided low molecular weight analogs such as compound 32, which is a 19nM DP-IV inhibitor with >4000-fold selectivity over QPP.Entities:
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Year: 2004 PMID： 15324904 DOI： 10.1016/j.bmcl.2004.06.065
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823