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Literature DB >> 1524966

In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.

L K Basco¹, C Gillotin, F Gimenez, R Farinotti, J Le Bras.

Abstract

The in vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline was compared against chloroquine-resistant and -susceptible strains of Plasmodium falciparum using a semi-micro drug susceptibility test. For each strain, the corresponding enantiomers exhibited similar activities. The enantiomers of halofantrine were the most active against both susceptible and resistant strains, followed by the enantiomers of mefloquine and enpiroline.

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Year: 1992 PMID： 1524966 PMCID： PMC1381440 DOI： 10.1111/j.1365-2125.1992.tb04081.x

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

11 in total

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Journal: Antimicrob Agents Chemother Date: 1978-06 Impact factor: 5.191

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21 in total

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3. The stereoselective distribution of halofantrine enantiomers within human, dog, and rat plasma lipoproteins.

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4. In vitro efficacy of dicationic compounds and mefloquine enantiomers against Echinococcus multilocularis metacestodes.

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Journal: Br J Clin Pharmacol Date: 1995-10 Impact factor: 4.335

6. In vitro and in vivo efficacies of mefloquine-based treatment against alveolar echinococcosis.

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Journal: Antimicrob Agents Chemother Date: 2010-12-06 Impact factor: 5.191

7. A randomized, double-blind, placebo-controlled study to investigate the safety, tolerability, and pharmacokinetics of single enantiomer (+)-mefloquine compared with racemic mefloquine in healthy persons.

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