Literature DB >> 6385737

Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects.

T M Cosgriff, E F Boudreau, C L Pamplin, J D Berman, M J Shmuklarsky, C J Canfield.   

Abstract

WR 180,409 (enpiroline) was administered to 22 non-immune subjects infected with the multi-drug resistant Vietnam Smith isolate of Plasmodium falciparum. It was curative in single day treatment regimens with a minimum curative dose of approximately 10 mg/kg body weight. At this dose level it was well tolerated and produced rapid clearance of parasitemia in every case.

Entities:  

Mesh：

Substances：

Year:  1984        PMID： 6385737     DOI： 10.4269/ajtmh.1984.33.767

Source DB:  PubMed          Journal:  Am J Trop Med Hyg        ISSN： 0002-9637            Impact factor:   2.345


  7 in total

1.  In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.

Authors:  L K Basco; C Gillotin; F Gimenez; R Farinotti; J Le Bras
Journal:  Br J Clin Pharmacol       Date:  1992-05       Impact factor: 4.335

2.  Antischistosomal activities of mefloquine-related arylmethanols.

Authors:  Katrin Ingram; William Ellis; Jennifer Keiser
Journal:  Antimicrob Agents Chemother       Date:  2012-04-02       Impact factor: 5.191

3.  Crystal and molecular structure of the antimalarial agent enpiroline.

Authors:  J M Karle; I L Karle
Journal:  Antimicrob Agents Chemother       Date:  1989-07       Impact factor: 5.191

Review 4.  Controlled Human Malaria Infection: Applications, Advances, and Challenges.

Authors:  Danielle I Stanisic; James S McCarthy; Michael F Good
Journal:  Infect Immun       Date:  2017-12-19       Impact factor: 3.441

5.  A pilot randomised trial of induced blood-stage Plasmodium falciparum infections in healthy volunteers for testing efficacy of new antimalarial drugs.

Authors:  James S McCarthy; Silvana Sekuloski; Paul M Griffin; Suzanne Elliott; Nanette Douglas; Chris Peatey; Rebecca Rockett; Peter O'Rourke; Louise Marquart; Cornelius Hermsen; Stephan Duparc; Jörg Möhrle; Katharine R Trenholme; Andrew J Humberstone
Journal:  PLoS One       Date:  2011-08-22       Impact factor: 3.240

6.  Liver Enzyme Elevations in Plasmodium falciparum Volunteer Infection Studies: Findings and Recommendations.

Authors:  Mohamed Farouk Chughlay; Samantha Akakpo; Anand Odedra; Katalin Csermak-Renner; Elhadj Djeriou; Cornelis Winnips; Didier Leboulleux; Aditya H Gaur; G Dennis Shanks; James McCarthy; Stephan Chalon
Journal:  Am J Trop Med Hyg       Date:  2020-04-16       Impact factor: 2.345

7.  Discovery of epi-Enprioline as a Novel Drug for the Treatment of Vincristine Resistant Neuroblastoma.

Authors:  Wondossen Sime; Mohamed Jemaà; Yasmin Abassi; Vito Alessandro Lasorsa; Julie Bonne Køhler; Karin Hansson; Daniel Bexell; Martin Michaelis; Jindrich Cinatl; Daniel Strand; Mario Capasso; Ramin Massoumi
Journal:  Int J Mol Sci       Date:  2020-09-08       Impact factor: 5.923
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.