Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

Literature DB >> 3527245

In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

S Fu, A Björkman, B Wåhlin, D Ofori-Adjei, O Ericsson, F Sjöqvist.

Abstract

A 48 h in vitro test was conducted to compare the susceptibility of two strains of Plasmodium falciparum to chloroquine, the two enantiomers of chloroquine, desethylchloroquine and the new antimalarial drug pyronaridine. The five compounds similarly inhibited the chloroquine sensitive strain. However, desethylchloroquine was less active and pyronaridine was much more active than chloroquine and its enantiomers against the chloroquine resistant strain.

Entities: Chemical Species

Mesh：

Substances：

Year: 1986 PMID： 3527245 PMCID： PMC1401091

Source DB: PubMed Journal: Br J Clin Pharmacol ISSN： 0306-5251 Impact factor: 4.335

11 in total

1. Blood levels and in vitro activity of desethylchloroquine against Plasmodium falciparum.

Authors: F Verdier; J Le Bras; F Clavier; I Hatin
Journal: Lancet Date: 1984-05-26 Impact factor: 79.321

2. [Polychemoresistant Plasmodium falciparum malaria, successfully treated with a benzonaphthyridine].

Authors: J Lapierre
Journal: Nouv Presse Med Date: 1982-02-27

3. Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test.

Authors: P Nguyen-Dinh; W Trager
Journal: Am J Trop Med Hyg Date: 1980-05 Impact factor: 2.345

In vitro activity of chloroquine, the two enantiomers of chloroquine, desethylchloroquine and pyronaridine against Plasmodium falciparum.

1. Blood levels and in vitro activity of desethylchloroquine against Plasmodium falciparum.

2. [Polychemoresistant Plasmodium falciparum malaria, successfully treated with a benzonaphthyridine].

3. Plasmodium falciparum in vitro: determination of chloroquine sensitivity of three new strains by a modified 48-hour test.

4. [The embryotoxicity of a new antimalarial pyronaridine in rats].

5. Human malaria parasites in continuous culture.

6. [Chloroquine enantiomers. Activity against P. vinckei and binding on DNA (author's transl)].

7. Disposition of chloroquine in man after single intravenous and oral doses.

8. Antimalarial activity of the optical isomers of chloroquine diphosphate.

9. In vitro assessment of the antimalarial activity of chloroquine and its major metabolites.

10. Human antibodies to a Mr 155,000 Plasmodium falciparum antigen efficiently inhibit merozoite invasion.

1. Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine.

2. In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.

Review 3. Chloroquine resistance in Plasmodium vivax.

Review 4. Drug treatment and prevention of malaria.

Review 5. Clinical pharmacokinetics and metabolism of chloroquine. Focus on recent advancements.

Review 6. Pharmacokinetics of quinine, chloroquine and amodiaquine. Clinical implications.

7. Stereoselective inhibition by chloroquine of histamine N-methyltransferase in the human liver and brain.

8. Protein binding of chloroquine enantiomers and desethylchloroquine.

9. Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans.

Review 10. Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiral antimalarial drugs.