| Literature DB >> 15225698 |
Dharmarajan Sriram1, Perumal Yogeeswari, Rathinasabapathy Thirumurugan.
Abstract
During the course of our work on the synthesis and screening of new drugs for tuberculosis, we have identified N1-(4-acetamido phenyl)-N4-(2-nitro benzylidene) semicarbazone (1b), which inhibited in vitro Mycobacterium tuberculosis H(37)Rv; 100% inhibition at 1.56 microg/mL. This paper is first of its kind in which aryl semicarbazones are reported to possess antimycobacterials potency greater than p-aminosalicylic acid, ethionamide, ethambutol, ciprofloxacin and kanamycin.Entities:
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Year: 2004 PMID： 15225698 DOI： 10.1016/j.bmcl.2004.05.060
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823