Literature DB >> 15105155

Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.

Sara Richter1, Cristina Parolin, Barbara Gatto, Claudia Del Vecchio, Egidio Brocca-Cofano, Arnaldo Fravolini, Giorgio Palù, Manlio Palumbo.   

Abstract

WM5, a 6-aminoquinolone derivative, binds with high affinity to the bulge of the trans-activation-responsive region (TAR), whereas it displays low binding affinity for the loop and stem regions of TAR and for random RNA and DNA sequences. Furthermore, WM5 disrupts the natural protein-nucleic acid complex with a 50% inhibitory concentration in the low micromolar range in both in vitro and in vivo assays.

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Year:  2004        PMID： 15105155      PMCID： PMC400552          DOI： 10.1128/AAC.48.5.1895-1899.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  35 in total

1.  Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: a new class of anti-HIV agents.

Authors:  M Hagihara; H Kashiwase; T Katsube; T Kimura; T Komai; K Momota; T Ohmine; T Nishigaki; S Kimura; K Shimada
Journal:  Bioorg Med Chem Lett       Date:  1999-11-01       Impact factor: 2.823

2.  Anti-HIV-1 activities and pharmacokinetics of new arylpiperazinyl fluoroquinolones.

Authors:  Toshinori Ohmine; Tetsushi Katsube; Yasunori Tsuzaki; Miho Kazui; Nobuhiro Kobayashi; Tomoaki Komai; Masahiko Hagihara; Takashi Nishigaki; Aikichi Iwamoto; Tomio Kimura; Hiroto Kashiwase; Makoto Yamashita
Journal:  Bioorg Med Chem Lett       Date:  2002-03-11       Impact factor: 2.823

3.  6-Aminoquinolones as new potential anti-HIV agents.

Authors:  V Cecchetti; C Parolin; S Moro; T Pecere; E Filipponi; A Calistri; O Tabarrini; B Gatto; M Palumbo; A Fravolini; G Palu'
Journal:  J Med Chem       Date:  2000-10-05       Impact factor: 7.446

4.  A new class of RNA-binding oligomers: peptoid amide and ester analogues.

Authors:  Venkitasamy Kesavan; Natarajan Tamilarasu; Hong Cao; Tariq M Rana
Journal:  Bioconjug Chem       Date:  2002 Nov-Dec       Impact factor: 4.774

5.  Selective binding of TAR RNA by a Tat-derived beta-peptide.

Authors:  Michael A Gelman; Sara Richter; Hong Cao; Naoki Umezawa; Samuel H Gellman; Tariq M Rana
Journal:  Org Lett       Date:  2003-10-02       Impact factor: 6.005

6.  Inhibition of the RNA-dependent transactivation and replication of human immunodeficiency virus type 1 by a fluoroquinoline derivative K-37.

Authors:  H Okamoto; T P Cujec; M Okamoto; B M Peterlin; M Baba; T Okamoto
Journal:  Virology       Date:  2000-07-05       Impact factor: 3.616

7.  HIV-1 tat trans-activation requires the loop sequence within tar.

Authors:  S Feng; E C Holland
Journal:  Nature       Date:  1988-07-14       Impact factor: 49.962

8.  Proximity of a Tat peptide to the HIV-1 TAR RNA loop region determined by site-specific photo-cross-linking.

Authors:  Z Wang; I Huq; T M Rana
Journal:  Bioconjug Chem       Date:  1999 May-Jun       Impact factor: 4.774

9.  New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action.

Authors:  Cristina Parolin; Barbara Gatto; Claudia Del Vecchio; Teresa Pecere; Enzo Tramontano; Violetta Cecchetti; Arnaldo Fravolini; Sara Masiero; Manlio Palumbo; Giorgio Palù
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

10.  Discovery of a small molecule Tat-trans-activation-responsive RNA antagonist that potently inhibits human immunodeficiency virus-1 replication.

Authors:  Seongwoo Hwang; Natarajan Tamilarasu; Karen Kibler; Hong Cao; Akbar Ali; Yueh-Hsin Ping; Kuan-Teh Jeang; Tariq M Rana
Journal:  J Biol Chem       Date:  2003-07-11       Impact factor: 5.157
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  19 in total

Review 1.  Face-time with TAR: Portraits of an HIV-1 RNA with diverse modes of effector recognition relevant for drug discovery.

Authors:  Sai Shashank Chavali; Rachel Bonn-Breach; Joseph E Wedekind
Journal:  J Biol Chem       Date:  2019-05-12       Impact factor: 5.157

Review 2.  Current Strategies for Elimination of HIV-1 Latent Reservoirs Using Chemical Compounds Targeting Host and Viral Factors.

Authors:  Maxime J Jean; Guillaume Fiches; Tsuyoshi Hayashi; Jian Zhu
Journal:  AIDS Res Hum Retroviruses       Date:  2018-12-12       Impact factor: 2.205

3.  Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.

Authors:  Trent Nguyen; Aaron Hamby; Stephen M Massa
Journal:  Proc Natl Acad Sci U S A       Date:  2005-08-08       Impact factor: 11.205

Review 4.  Advances toward Curing HIV-1 Infection in Tissue Reservoirs.

Authors:  Lisa J Henderson; Lauren B Reoma; Joseph A Kovacs; Avindra Nath
Journal:  J Virol       Date:  2020-01-17       Impact factor: 5.103

5.  Novel in vivo model for the study of human immunodeficiency virus type 1 transcription inhibitors: evaluation of new 6-desfluoroquinolone derivatives.

Authors:  Miguel Stevens; Michela Pollicita; Christophe Pannecouque; Erik Verbeken; Oriana Tabarrini; Violetta Cecchetti; Stefano Aquaro; Carlo Federico Perno; Arnaldo Fravolini; Erik De Clercq; Dominique Schols; Jan Balzarini
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

Review 6.  Targeting HIV transcription: the quest for a functional cure.

Authors:  Guillaume Mousseau; Sonia Mediouni; Susana T Valente
Journal:  Curr Top Microbiol Immunol       Date:  2015       Impact factor: 4.291

7.  Inhibition of HIV-1 Tat-mediated transcription by a coumarin derivative, BPRHIV001, through the Akt pathway.

Authors:  Pi-Han Lin; Yi-Yu Ke; Chun-Ting Su; Hui-Yi Shiao; Hsing-Pang Hsieh; Yu-Kai Chao; Chun-Nan Lee; Chuan-Liang Kao; Yu-Sheng Chao; Sui-Yuan Chang
Journal:  J Virol       Date:  2011-06-22       Impact factor: 5.103

8.  The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.

Authors:  Arianna Loregian; Beatrice Mercorelli; Giulia Muratore; Elisa Sinigalia; Silvana Pagni; Serena Massari; Giorgio Gribaudo; Barbara Gatto; Manlio Palumbo; Oriana Tabarrini; Violetta Cecchetti; Giorgio Palù
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

9.  A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity.

Authors:  Beatrice Mercorelli; Giulia Muratore; Elisa Sinigalia; Oriana Tabarrini; Maria Angela Biasolo; Violetta Cecchetti; Giorgio Palù; Arianna Loregian
Journal:  Antimicrob Agents Chemother       Date:  2008-11-17       Impact factor: 5.191

10.  Structure of HIV TAR in complex with a Lab-Evolved RRM provides insight into duplex RNA recognition and synthesis of a constrained peptide that impairs transcription.

Authors:  Ivan A Belashov; David W Crawford; Chapin E Cavender; Peng Dai; Patrick C Beardslee; David H Mathews; Bradley L Pentelute; Brian R McNaughton; Joseph E Wedekind
Journal:  Nucleic Acids Res       Date:  2018-07-27       Impact factor: 16.971
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