| Literature DB >> 10560726 |
M Hagihara1, H Kashiwase, T Katsube, T Kimura, T Komai, K Momota, T Ohmine, T Nishigaki, S Kimura, K Shimada.
Abstract
Synthesis and anti-HIV activity of a series of novel arylpiperazinyl fluoroquinolones are reported. In the SAR study, the aryl substituents on the piperazine nitrogen were found to play an important role for the anti-HIV-1 activity. A few of the compounds exhibited potent anti-HIV activity: IC50=0.06 microM in chronically infected cells.Entities:
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Year: 1999 PMID： 10560726 DOI： 10.1016/s0960-894x(99)00537-5
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823