Literature DB >> 19015358

A 6-aminoquinolone compound, WC5, with potent and selective anti-human cytomegalovirus activity.

Beatrice Mercorelli1, Giulia Muratore, Elisa Sinigalia, Oriana Tabarrini, Maria Angela Biasolo, Violetta Cecchetti, Giorgio Palù, Arianna Loregian.   

Abstract

We identified a 6-aminoquinolone compound, WC5, that inhibits human cytomegalovirus (HCMV) replication with a selectivity index of approximately 500. WC5 also showed activity against drug-resistant HCMV strains. In contrast, it did not significantly affect the replication of human herpesvirus 6 and 8 and was approximately 10-fold less active against murine cytomegalovirus. Thus, WC5 may represent a lead for the development of new, potent, and selective anti-HCMV compounds.

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Year:  2008        PMID： 19015358      PMCID： PMC2612181          DOI： 10.1128/AAC.00988-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Synthesis and anti-HIV activity of arylpiperazinyl fluoroquinolones: a new class of anti-HIV agents.

Authors:  M Hagihara; H Kashiwase; T Katsube; T Kimura; T Komai; K Momota; T Ohmine; T Nishigaki; S Kimura; K Shimada
Journal:  Bioorg Med Chem Lett       Date:  1999-11-01       Impact factor: 2.823

Review 2.  Antiherpesvirus drugs: a promising spectrum of new drugs and drug targets.

Authors:  Donald M Coen; Priscilla A Schaffer
Journal:  Nat Rev Drug Discov       Date:  2003-04       Impact factor: 84.694

3.  6-Aminoquinolones as new potential anti-HIV agents.

Authors:  V Cecchetti; C Parolin; S Moro; T Pecere; E Filipponi; A Calistri; O Tabarrini; B Gatto; M Palumbo; A Fravolini; G Palu'
Journal:  J Med Chem       Date:  2000-10-05       Impact factor: 7.446

4.  A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.

Authors:  V Sullivan; C L Talarico; S C Stanat; M Davis; D M Coen; K K Biron
Journal:  Nature       Date:  1992-09-03       Impact factor: 49.962

5.  Inhibition of human immunodeficiency virus type 1 tat-trans-activation-responsive region interaction by an antiviral quinolone derivative.

Authors:  Sara Richter; Cristina Parolin; Barbara Gatto; Claudia Del Vecchio; Egidio Brocca-Cofano; Arnaldo Fravolini; Giorgio Palù; Manlio Palumbo
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191

6.  Isolation of foscarnet-resistant human cytomegalovirus patterns of resistance and sensitivity to other antiviral drugs.

Authors:  V Sullivan; D M Coen
Journal:  J Infect Dis       Date:  1991-10       Impact factor: 5.226

7.  New anti-human immunodeficiency virus type 1 6-aminoquinolones: mechanism of action.

Authors:  Cristina Parolin; Barbara Gatto; Claudia Del Vecchio; Teresa Pecere; Enzo Tramontano; Violetta Cecchetti; Arnaldo Fravolini; Sara Masiero; Manlio Palumbo; Giorgio Palù
Journal:  Antimicrob Agents Chemother       Date:  2003-03       Impact factor: 5.191

8.  Structure modifications of 6-aminoquinolones with potent anti-HIV activity.

Authors:  Oriana Tabarrini; Miguel Stevens; Violetta Cecchetti; Stefano Sabatini; Micaela Dell'Uomo; Giuseppe Manfroni; Manlio Palumbo; Christophe Pannecouque; Erik De Clercq; Arnaldo Fravolini
Journal:  J Med Chem       Date:  2004-10-21       Impact factor: 7.446

9.  Selective anti-cytomegalovirus compounds discovered by screening for inhibitors of subunit interactions of the viral polymerase.

Authors:  Arianna Loregian; Donald M Coen
Journal:  Chem Biol       Date:  2006-02

Review 10.  Antiviral properties of quinolone-based drugs.

Authors:  Sara Richter; Cristina Parolin; Manlio Palumbo; Giorgio Palù
Journal:  Curr Drug Targets Infect Disord       Date:  2004-06
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  11 in total

1.  The 6-Aminoquinolone WC5 inhibits different functions of the immediate-early 2 (IE2) protein of human cytomegalovirus that are essential for viral replication.

Authors:  Beatrice Mercorelli; Anna Luganini; Giulia Muratore; Serena Massari; Maria Elena Terlizzi; Oriana Tabarrini; Giorgio Gribaudo; Giorgio Palù; Arianna Loregian
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

2.  The 6-aminoquinolone WC5 inhibits human cytomegalovirus replication at an early stage by interfering with the transactivating activity of viral immediate-early 2 protein.

Authors:  Arianna Loregian; Beatrice Mercorelli; Giulia Muratore; Elisa Sinigalia; Silvana Pagni; Serena Massari; Giorgio Gribaudo; Barbara Gatto; Manlio Palumbo; Oriana Tabarrini; Violetta Cecchetti; Giorgio Palù
Journal:  Antimicrob Agents Chemother       Date:  2010-03-01       Impact factor: 5.191

3.  Human cytomegalovirus inhibitor AL18 also possesses activity against influenza A and B viruses.

Authors:  Giulia Muratore; Beatrice Mercorelli; Laura Goracci; Gabriele Cruciani; Paul Digard; Giorgio Palù; Arianna Loregian
Journal:  Antimicrob Agents Chemother       Date:  2012-08-20       Impact factor: 5.191

4.  The Clinically Approved Antifungal Drug Posaconazole Inhibits Human Cytomegalovirus Replication.

Authors:  Beatrice Mercorelli; Anna Luganini; Marta Celegato; Giorgio Palù; Giorgio Gribaudo; Galina I Lepesheva; Arianna Loregian
Journal:  Antimicrob Agents Chemother       Date:  2020-09-21       Impact factor: 5.191

5.  The antifungal drug isavuconazole inhibits the replication of human cytomegalovirus (HCMV) and acts synergistically with anti-HCMV drugs.

Authors:  Beatrice Mercorelli; Marta Celegato; Anna Luganini; Giorgio Gribaudo; Galina I Lepesheva; Arianna Loregian
Journal:  Antiviral Res       Date:  2021-03-13       Impact factor: 5.970

6.  Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.

Authors:  Ran He; Gordon Sandford; Gary S Hayward; William H Burns; Gary H Posner; Michael Forman; Ravit Arav-Boger
Journal:  Virol J       Date:  2011-01-26       Impact factor: 4.099

7.  A quantitative LumiFluo assay to test inhibitory compounds blocking p53 degradation induced by human papillomavirus oncoprotein E6 in living cells.

Authors:  Lorenzo Messa; Marta Celegato; Chiara Bertagnin; Beatrice Mercorelli; Giulio Nannetti; Giorgio Palù; Arianna Loregian
Journal:  Sci Rep       Date:  2018-04-16       Impact factor: 4.379

Review 8.  Early inhibitors of human cytomegalovirus: state-of-art and therapeutic perspectives.

Authors:  Beatrice Mercorelli; David Lembo; Giorgio Palù; Arianna Loregian
Journal:  Pharmacol Ther       Date:  2011-04-28       Impact factor: 12.310

9.  The Biochemical and Molecular Analysis of Changes in Melanogenesis Induced by UVA-Activated Fluoroquinolones-In Vitro Study on Human Normal Melanocytes.

Authors:  Justyna Kowalska; Klaudia Banach; Artur Beberok; Jakub Rok; Zuzanna Rzepka; Dorota Wrześniok
Journal:  Cells       Date:  2021-10-27       Impact factor: 6.600

Review 10.  Bright and Early: Inhibiting Human Cytomegalovirus by Targeting Major Immediate-Early Gene Expression or Protein Function.

Authors:  Catherine S Adamson; Michael M Nevels
Journal:  Viruses       Date:  2020-01-16       Impact factor: 5.048
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