| Literature DB >> 11858992 |
Toshinori Ohmine1, Tetsushi Katsube, Yasunori Tsuzaki, Miho Kazui, Nobuhiro Kobayashi, Tomoaki Komai, Masahiko Hagihara, Takashi Nishigaki, Aikichi Iwamoto, Tomio Kimura, Hiroto Kashiwase, Makoto Yamashita.
Abstract
Anti-HIV-1 activities and pharmacokinetics of a series of novel arylpiperazinyl fluoroquinolones are reported. Modification at the C-8 position with a trifluoromethyl group was superior to that with a difluoromethoxy group to achieve higher anti-HIV-1 activity. Two compounds studied exhibited quite high anti-HIV-1 activities (IC(50)<50 nM) in vitro and high bioavailabilities (BA>90%) in monkeys.Entities:
Mesh：
Substances：
Year: 2002 PMID： 11858992 DOI： 10.1016/s0960-894x(02)00003-3
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823