Literature DB >> 15105154

Iron blocks the accumulation and activity of tetracyclines in bacteria.

Angela M Avery1, Helen J Goddard, Edward R Sumner, Simon V Avery.   

Abstract

The apparent sensitivities of several bacterial pathogens to tetracyclines varied by up to 128-fold with the medium content of Fe, but not of other metals. The effect of Fe was independent of superoxide dismutase activity and of intracellular Fe, but accumulation of tetracyclines was blocked in high-Fe medium. Thus, synergistic suppression of bacterial growth in the presence of a low Fe concentration and tetracyclines arises because of elevated antibiotic accumulation.

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Year:  2004        PMID： 15105154      PMCID： PMC400538          DOI： 10.1128/AAC.48.5.1892-1894.2004

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  21 in total

1.  In vitro activities of antibiotics against Plasmodium falciparum are inhibited by iron.

Authors:  B Pradines; C Rogier; T Fusai; J Mosnier; W Daries; E Barret; D Parzy
Journal:  Antimicrob Agents Chemother       Date:  2001-06       Impact factor: 5.191

Review 2.  Iron uptake mechanisms and their regulation in pathogenic bacteria.

Authors:  V Braun
Journal:  Int J Med Microbiol       Date:  2001-05       Impact factor: 3.473

3.  Iron-chelating activity of tetracyclines and its impact on the susceptibility of Actinobacillus actinomycetemcomitans to these antibiotics.

Authors:  D Grenier; M P Huot; D Mayrand
Journal:  Antimicrob Agents Chemother       Date:  2000-03       Impact factor: 5.191

4.  Copper/zinc-Superoxide dismutase is required for oxytetracycline resistance of Saccharomyces cerevisiae.

Authors:  S V Avery; S Malkapuram; C Mateus; K S Babb
Journal:  J Bacteriol       Date:  2000-01       Impact factor: 3.490

5.  Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics.

Authors:  F E Angrave; S V Avery
Journal:  Antimicrob Agents Chemother       Date:  2001-10       Impact factor: 5.191

6.  Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.

Authors:  I Chopra; M Roberts
Journal:  Microbiol Mol Biol Rev       Date:  2001-06       Impact factor: 11.056

7.  The effects of environmental conditions on the in vitro activity of selected antimicrobial agents against Escherichia coli.

Authors:  J Nanavaty; J E Mortensen; T R Shryock
Journal:  Curr Microbiol       Date:  1998-04       Impact factor: 2.188

8.  Lethal oxidative damage and mutagenesis are generated by iron in delta fur mutants of Escherichia coli: protective role of superoxide dismutase.

Authors:  D Touati; M Jacques; B Tardat; L Bouchard; S Despied
Journal:  J Bacteriol       Date:  1995-05       Impact factor: 3.490

9.  Iron deficiency-induced tetracycline production in submerged cultures by Streptomyces aureofaciens.

Authors:  M Béchet; R Blondeau
Journal:  J Appl Microbiol       Date:  1998-05       Impact factor: 3.772

10.  Role of outer membrane barrier in efflux-mediated tetracycline resistance of Escherichia coli.

Authors:  D G Thanassi; G S Suh; H Nikaido
Journal:  J Bacteriol       Date:  1995-02       Impact factor: 3.490
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  7 in total

Review 1.  rRNA Binding Sites and the Molecular Mechanism of Action of the Tetracyclines.

Authors:  Chinwe U Chukwudi
Journal:  Antimicrob Agents Chemother       Date:  2016-07-22       Impact factor: 5.191

2.  Machine Learning of Bacterial Transcriptomes Reveals Responses Underlying Differential Antibiotic Susceptibility.

Authors:  Anand V Sastry; Nicholas Dillon; Amitesh Anand; Saugat Poudel; Ying Hefner; Sibei Xu; Richard Szubin; Adam M Feist; Victor Nizet; Bernhard Palsson
Journal:  mSphere       Date:  2021-08-25       Impact factor: 5.029

3.  Design of Polymeric Thin Films to Direct Microbial Biofilm Growth, Virulence, and Metabolism.

Authors:  Trevor Franklin; Yinan Wu; Jiayan Lang; Sijin Li; Rong Yang
Journal:  Biomacromolecules       Date:  2021-10-25       Impact factor: 6.978

4.  Doxycycline-regulated gene expression in the opportunistic fungal pathogen Aspergillus fumigatus.

Authors:  Keith Vogt; Ruchi Bhabhra; Judith C Rhodes; David S Askew
Journal:  BMC Microbiol       Date:  2005-01-13       Impact factor: 3.605

5.  The ferrous iron-responsive BqsRS two-component system activates genes that promote cationic stress tolerance.

Authors:  Naomi N Kreamer; Flavia Costa; Dianne K Newman
Journal:  MBio       Date:  2015-02-24       Impact factor: 7.867

6.  A manganese photosensitive tricarbonyl molecule [Mn(CO)3(tpa-κ3N)]Br enhances antibiotic efficacy in a multi-drug-resistant Escherichia coli.

Authors:  Namrata Rana; Helen E Jesse; Mariana Tinajero-Trejo; Jonathan A Butler; John D Tarlit; Milena L von Und Zur Muhlen; Christoph Nagel; Ulrich Schatzschneider; Robert K Poole
Journal:  Microbiology (Reading)       Date:  2017-09-28       Impact factor: 2.777

Review 7.  The Pseudomonas Quinolone Signal (PQS): Not Just for Quorum Sensing Anymore.

Authors:  Jinshui Lin; Juanli Cheng; Yao Wang; Xihui Shen
Journal:  Front Cell Infect Microbiol       Date:  2018-07-04       Impact factor: 5.293
  7 in total

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