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Literature DB >> 11557497

Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics.

Abstract

Cu,Zn superoxide dismutase (Sod1) is required for insusceptibility of Saccharomyces cerevisiae to oxytetracycline (OTC). Here we report that Sod1 is also required for insusceptibility to doxycycline (DOX). Furthermore, among a range of antioxidant and redox balance mutants, mac1 and ctr1 deletion strains exhibited marked sensitization to OTC and DOX. Certain mutants exhibited a slight sensitivity to methacycline and minocycline. Addition of copper suppressed antibiotic sensitivity. Thus, intracellular copper as well as superoxide dismutase can be critical for eukaryotic tolerance of several tetracycline antibiotics.

Entities: Chemical Gene Species

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Year: 2001 PMID： 11557497 PMCID： PMC90759 DOI： 10.1128/AAC.45.10.2939-2942.2001

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

21 in total

1. Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

Authors: T D Rae; P J Schmidt; R A Pufahl; V C Culotta; T V O'Halloran
Journal: Science Date: 1999-04-30 Impact factor: 47.728

2. METAL COMPLEXATION OF THE TETRACYCLINE HYDROCHLORIDES.

Authors: J T DOLUISIO; A N MARTIN
Journal: J Med Chem Date: 1963-01 Impact factor: 7.446

Review 3. Iron and copper transport in yeast and its relevance to human disease.

Authors: C Askwith; J Kaplan
Journal: Trends Biochem Sci Date: 1998-04 Impact factor: 13.807

Review 4. Tetracyclines: antibiotic action, uptake, and resistance mechanisms.

Authors: D Schnappinger; W Hillen
Journal: Arch Microbiol Date: 1996-06 Impact factor: 2.552

5. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway.

Authors: S Labbé; Z Zhu; D J Thiele
Journal: J Biol Chem Date: 1997-06-20 Impact factor: 5.157

3. Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes.

Authors: Alexandra S Blackburn; Simon V Avery
Journal: Antimicrob Agents Chemother Date: 2003-02 Impact factor: 5.191

3 in total

Antioxidant functions required for insusceptibility of Saccharomyces cerevisiae to tetracycline antibiotics.

1. Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase.

2. METAL COMPLEXATION OF THE TETRACYCLINE HYDROCHLORIDES.

Review 3. Iron and copper transport in yeast and its relevance to human disease.

Review 4. Tetracyclines: antibiotic action, uptake, and resistance mechanisms.

5. Copper-specific transcriptional repression of yeast genes encoding critical components in the copper transport pathway.

6. Copper/zinc-Superoxide dismutase is required for oxytetracycline resistance of Saccharomyces cerevisiae.

7. Heterologous HIS3 marker and GFP reporter modules for PCR-targeting in Saccharomyces cerevisiae.

8. Tetracycline antibiotics: mode of action, applications, molecular biology, and epidemiology of bacterial resistance.

9. Yeast lacking Cu-Zn superoxide dismutase show altered iron homeostasis. Role of oxidative stress in iron metabolism.

Review 10. Oxidative stress responses of the yeast Saccharomyces cerevisiae.

1. Iron homeostasis affects antibiotic-mediated cell death in Pseudomonas species.

2. Iron blocks the accumulation and activity of tetracyclines in bacteria.

3. Genome-wide screening of Saccharomyces cerevisiae to identify genes required for antibiotic insusceptibility of eukaryotes.