| Literature DB >> 15105119 |
Claire Héritier1, Laurent Poirel, Patrice Nordmann.
Abstract
A chromosome-encoded beta-lactamase gene from Shewanella algae clinical isolate KB-1 was cloned and expressed in Escherichia coli. It encoded the Ambler class D enzyme OXA-55, sharing less than 55% identity with any other oxacillinases. Although conferring a narrow-spectrum beta-lactam resistance phenotype, OXA-55 had carbapenem-hydrolyzing activity that mirrored the reduced susceptibility to imipenem observed in S. algae KB-1. Very similar oxacillinases were found in other S. algae isolates.Entities:
Mesh:
Substances:
Year: 2004 PMID: 15105119 PMCID: PMC400541 DOI: 10.1128/AAC.48.5.1670-1675.2004
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191