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Literature DB >> 16189095

Characterization of the naturally occurring oxacillinase of Acinetobacter baumannii.

Claire Héritier¹, Laurent Poirel, Pierre-Edouard Fournier, Jean-Michel Claverie, Didier Raoult, Patrice Nordmann.

Abstract

A chromosomally encoded oxacillinase, OXA-69, was characterized from Acinetobacter baumannii AYE. beta-Lactamase OXA-69 shared 97% amino acid identity with the recently described OXA-51 enzyme of A. baumannii and 62 and 56% amino acid identity with the carbapenem-hydrolyzing oxacillinases OXA-24 and OXA-23, respectively. Biochemical characterization of the purified OXA-69 revealed a narrow-spectrum hydrolysis profile but including, at a low level, imipenem and meropenem. By PCR and sequencing bla(OXA-69)-like genes were identified in all A. baumannii strains tested (n = 12), suggesting that this oxacillinase is naturally occurring in that species.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2005 PMID： 16189095 PMCID： PMC1251506 DOI： 10.1128/AAC.49.10.4174-4179.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

33 in total

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4. Emergence of PER-2 and VEB-1a in Acinetobacter baumannii Strains in the Americas.

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7. Clonal spread of imipenem-resistant Acinetobacter baumannii among different cities of China.

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Review 8. Carbapenemases: the versatile beta-lactamases.

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Authors: Samy Figueiredo; Laurent Poirel; Jacques Croize; Christine Recule; Patrice Nordmann
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10. Crystal structure of carbapenemase OXA-58 from Acinetobacter baumannii.

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