Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.

Literature DB >> 15616297

OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.

Laurent Poirel¹, Sophie Marqué, Claire Héritier, Christine Segonds, Gérard Chabanon, Patrice Nordmann.

Abstract

A carbapenem-resistant Acinetobacter baumannii strain was isolated in Toulouse, France, in 2003. Cloning and expression in Escherichia coli identified the carbapenem-hydrolyzing beta-lactamase OXA-58, which is weakly related (less than 50% amino acid identity) to other oxacillinases. It hydrolyzed penicillins, oxacillin, and imipenem but not expanded-spectrum cephalosporins. The bla(OXA-58) gene was located on a ca. 30-kb non-self-transferable plasmid. After electrotransformation in the A. baumannii CIP7010(T) reference strain, it conferred reduced susceptibility to carbapenems. The bla(OXA-58) gene was bracketed by two novel ISAba3-like insertion elements. This study describes a newly characterized beta-lactamase that may contribute to carbapenem resistance in A. baumannii.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2005 PMID： 15616297 PMCID： PMC538857 DOI： 10.1128/AAC.49.1.202-208.2005

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

37 in total

1. Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.

Authors: D Aubert; L Poirel; J Chevalier; S Leotard; J M Pages; P Nordmann
Journal: Antimicrob Agents Chemother Date: 2001-06 Impact factor: 5.191

2. Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC beta-lactamase in Acinetobacter baumannii.

Authors: G Bou; J Martínez-Beltrán
Journal: Antimicrob Agents Chemother Date: 2000-02 Impact factor: 5.191

3. OXA-28, an extended-spectrum variant of OXA-10 beta-lactamase from Pseudomonas aeruginosa and its plasmid- and integron-located gene.

Authors: L Poirel; D Girlich; T Naas; P Nordmann
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

4. Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein.

Authors: R B Clark
Journal: J Antimicrob Chemother Date: 1996-08 Impact factor: 5.790

5. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of beta-lactamases.

Authors: G Bou; G Cerveró; M A Domínguez; C Quereda; J Martínez-Beltrán
Journal: J Clin Microbiol Date: 2000-09 Impact factor: 5.948

6. OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.

Authors: G Bou; A Oliver; J Martínez-Beltrán
Journal: Antimicrob Agents Chemother Date: 2000-06 Impact factor: 5.191

Review 7. Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support.

Authors: L Poirel; P Nordmann
Journal: Curr Pharm Biotechnol Date: 2002-06 Impact factor: 2.837

8. OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.

Authors: L N Philippon; T Naas; A T Bouthors; V Barakett; P Nordmann
Journal: Antimicrob Agents Chemother Date: 1997-10 Impact factor: 5.191

9. PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron.

Authors: Naohiro Shibata; Yohei Doi; Kunikazu Yamane; Tetsuya Yagi; Hiroshi Kurokawa; Keigo Shibayama; Haru Kato; Kumiko Kai; Yoshichika Arakawa
Journal: J Clin Microbiol Date: 2003-12 Impact factor: 5.948

10. Genetic environment and transcription of ampC in an Acinetobacter baumannii clinical isolate.

Authors: Heidi Segal; E C Nelson; B Gay Elisha
Journal: Antimicrob Agents Chemother Date: 2004-02 Impact factor: 5.191

100 in total

1. A Diverse Panel of Clinical Acinetobacter baumannii for Research and Development.

Authors: Madeline R Galac; Erik Snesrud; Francois Lebreton; Jason Stam; Michael Julius; Ana C Ong; Rosslyn Maybank; Anthony R Jones; Yoon I Kwak; Kate Hinkle; Paige E Waterman; Emil P Lesho; Jason W Bennett; Patrick Mc Gann
Journal: Antimicrob Agents Chemother Date: 2020-09-21 Impact factor: 5.191

2. OXA-58 and IMP-4 carbapenem-hydrolyzing beta-lactamases in an Acinetobacter junii blood culture isolate from Australia.

Authors: Anton Y Peleg; Clare Franklin; Luke J Walters; Jan M Bell; Denis W Spelman
Journal: Antimicrob Agents Chemother Date: 2006-01 Impact factor: 5.191

OXA-58, a novel class D {beta}-lactamase involved in resistance to carbapenems in Acinetobacter baumannii.

1. Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa.

2. Cloning, nucleotide sequencing, and analysis of the gene encoding an AmpC beta-lactamase in Acinetobacter baumannii.

3. OXA-28, an extended-spectrum variant of OXA-10 beta-lactamase from Pseudomonas aeruginosa and its plasmid- and integron-located gene.

4. Imipenem resistance among Acinetobacter baumannii: association with reduced expression of a 33-36 kDa outer membrane protein.

5. Characterization of a nosocomial outbreak caused by a multiresistant Acinetobacter baumannii strain with a carbapenem-hydrolyzing enzyme: high-level carbapenem resistance in A. baumannii is not due solely to the presence of beta-lactamases.

6. OXA-24, a novel class D beta-lactamase with carbapenemase activity in an Acinetobacter baumannii clinical strain.

Review 7. Acquired carbapenem-hydrolyzing beta-lactamases and their genetic support.

8. OXA-18, a class D clavulanic acid-inhibited extended-spectrum beta-lactamase from Pseudomonas aeruginosa.

9. PCR typing of genetic determinants for metallo-beta-lactamases and integrases carried by gram-negative bacteria isolated in Japan, with focus on the class 3 integron.

10. Genetic environment and transcription of ampC in an Acinetobacter baumannii clinical isolate.

1. A Diverse Panel of Clinical Acinetobacter baumannii for Research and Development.

2. OXA-58 and IMP-4 carbapenem-hydrolyzing beta-lactamases in an Acinetobacter junii blood culture isolate from Australia.

3. Occurrence of OXA-58-like carbapenemases in Acinetobacter spp. collected over 10 years in three continents.

4. First report of the carbapenem-hydrolyzing oxacillinase OXA-58 in Acinetobacter baumannii isolates in Italy.

5. Emergence of PER-2 and VEB-1a in Acinetobacter baumannii Strains in the Americas.

6. Genetics and expression of the carbapenem-hydrolyzing oxacillinase gene blaOXA-23 in Acinetobacter baumannii.

7. High prevalence of the PER-1 gene among carbapenem-resistant Acinetobacter baumannii in Riyadh, Saudi Arabia.

8. OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.

9. Crystal structure of carbapenemase OXA-58 from Acinetobacter baumannii.

10. Class D β-lactamases: are they all carbapenemases?