OBJECTIVE: To determine the efficacy of single blastocyst transfer. DESIGN: Prospective randomized trial. SETTING: Private assisted reproductive technology unit. PATIENT(S): Forty-eight women undergoing IVF-embryo transfer with day 3FSH <or=10 mIU/mL and at least 10 follicles >12 mm in diameter on day of hCG administration. INTERVENTION(S): Embryo culture to the blastocyst stage in sequential media G1/G2 followed by transfer of either one or two blastocysts. MAIN OUTCOME MEASURE(S): Implantation rate, ongoing pregnancy rate, and twinning. RESULT(S): The transfer of a single blastocyst resulted in an implantation and ongoing pregnancy rate of 60.9% with no twins. The transfer of two blastocysts resulted in an implantation rate of 56%, an ongoing pregnancy rate of 76% with a 47.4% incidence of twins. CONCLUSION(S): Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.
RCT Entities:
OBJECTIVE: To determine the efficacy of single blastocyst transfer. DESIGN: Prospective randomized trial. SETTING: Private assisted reproductive technology unit. PATIENT(S): Forty-eight women undergoing IVF-embryo transfer with day 3 FSH <or=10 mIU/mL and at least 10 follicles >12 mm in diameter on day of hCG administration. INTERVENTION(S): Embryo culture to the blastocyst stage in sequential media G1/G2 followed by transfer of either one or two blastocysts. MAIN OUTCOME MEASURE(S): Implantation rate, ongoing pregnancy rate, and twinning. RESULT(S): The transfer of a single blastocyst resulted in an implantation and ongoing pregnancy rate of 60.9% with no twins. The transfer of two blastocysts resulted in an implantation rate of 56%, an ongoing pregnancy rate of 76% with a 47.4% incidence of twins. CONCLUSION(S): Single blastocyst transfer is an effective method of eliminating multiple births while maintaining high pregnancy rates in this selected group of patients.
Authors: Kirstine Kirkegaard; Johnny Juhl Hindkjaer; Marie Louise Grøndahl; Ulrik Schiøler Kesmodel; Hans Jakob Ingerslev Journal: J Assist Reprod Genet Date: 2012-03-30 Impact factor: 3.412