PURPOSE: To determine if the elective transfer of two embryos reduced the incidence of multiple gestations while maintaining high pregnancy rates. METHODS: IVF patients and recipients of oocyte donation with an elective day-3 transfer of 2 or 3 embryos were studied. RESULT(S): In IVF, the elective transfer of 2 embryos resulted in similar pregnancy rate but significantly reduced the overall incidence of multiple gestations (20% versus 39%) when compared to the elective transfer of 3 embryos. Twin gestations decreased from 28% to 19%, and triplets significantly decreased from 9% to 1%. In oocyte donation, the elective transfer of 2 embryos resulted in similar pregnancy rate but also significantly reduced the overall incidence of multiple gestations (26% versus 48%), with twins decreasing from 34% to 24%, and with a significant reduction of triplets (13% versus 2%). CONCLUSIONS: In IVF and oocyte donation, the elective transfer of 2 embryos resulted in similar pregnancy rates and significantly reduced multiple gestation rates when compared to the elective transfer of 3 embryos.
PURPOSE: To determine if the elective transfer of two embryos reduced the incidence of multiple gestations while maintaining high pregnancy rates. METHODS:IVFpatients and recipients of oocyte donation with an elective day-3 transfer of 2 or 3 embryos were studied. RESULT(S): In IVF, the elective transfer of 2 embryos resulted in similar pregnancy rate but significantly reduced the overall incidence of multiple gestations (20% versus 39%) when compared to the elective transfer of 3 embryos. Twin gestations decreased from 28% to 19%, and triplets significantly decreased from 9% to 1%. In oocyte donation, the elective transfer of 2 embryos resulted in similar pregnancy rate but also significantly reduced the overall incidence of multiple gestations (26% versus 48%), with twins decreasing from 34% to 24%, and with a significant reduction of triplets (13% versus 2%). CONCLUSIONS: In IVF and oocyte donation, the elective transfer of 2 embryos resulted in similar pregnancy rates and significantly reduced multiple gestation rates when compared to the elective transfer of 3 embryos.
Authors: Eli Y Adashi; Pedro N Barri; Richard Berkowitz; Peter Braude; Elizabeth Bryan; Judith Carr; Jean Cohen; John Collins; Paul Devroey; René Frydman; David Gardner; Marc Germond; Jan Gerris; Luca Gianaroli; Lars Hamberger; Colin Howles; Howard Jones; Bruno Lunenfeld; Andrew Pope; Meredith Reynolds; Zev Rosenwaks; Laura A Shieve; Gama I Serour; Françoise Shenfield; Allan Templeton; André van Steirteghem; Lucinda Veeck; Ulla-Britt Wennerholm Journal: Reprod Biomed Online Date: 2003-11 Impact factor: 3.828
Authors: Hind A Beydoun; Nicholas Sicignano; May A Beydoun; David O Matson; Silvina Bocca; Laurel Stadtmauer; Sergio Oehninger Journal: Fertil Steril Date: 2010-02-16 Impact factor: 7.329