Literature DB >> 15035477

Label-free detection of microarrays of biomolecules by oblique-incidence reflectivity difference microscopy.

J P Landry1, X D Zhu, J P Gregg.   

Abstract

We developed an oblique-incidence reflectivity difference (OI-RD) scanning microscope for label-free imaging of microarrays of biomolecules upon solid substrates. We demonstrate that hybridization reactions in an oligonucleotide microarray fabricated upon a glass slide can be detected by such an OI-RD microscope.

Mesh：

Year:  2004        PMID： 15035477     DOI： 10.1364/ol.29.000581

Source DB:  PubMed          Journal:  Opt Lett        ISSN： 0146-9592            Impact factor:   3.776


  20 in total

1.  Simultaneous measurement of 10,000 protein-ligand affinity constants using microarray-based kinetic constant assays.

Authors:  James P Landry; Yiyan Fei; Xiangdong Zhu
Journal:  Assay Drug Dev Technol       Date:  2011-12-22       Impact factor: 1.738

2.  Distance-dependent intrinsic fluorescence of proteins on aluminum nanostructures.

Authors:  Nuriye Akbay; Joseph R Lakowicz; Krishanu Ray
Journal:  Proc SPIE Int Soc Opt Eng       Date:  2012-02-09

3.  Oblique-incidence reflectivity difference microscope for label-free high-throughput detection of biochemical reactions in a microarray format.

Authors:  Xiangdong Zhu; James P Landry; Yung-Shin Sun; Jeff P Gregg; Kit S Lam; Xiaowen Guo
Journal:  Appl Opt       Date:  2007-04-01       Impact factor: 1.980

4.  A novel high-throughput scanning microscope for label-free detection of protein and small-molecule chemical microarrays.

Authors:  Y Y Fei; J P Landry; Y S Sun; X D Zhu; J T Luo; X B Wang; K S Lam
Journal:  Rev Sci Instrum       Date:  2008-01       Impact factor: 1.523

5.  Protein reactions with surface-bound molecular targets detected by oblique-incidence reflectivity difference microscopes.

Authors:  J P Landry; Y S Sun; X W Guo; X D Zhu
Journal:  Appl Opt       Date:  2008-06-20       Impact factor: 1.980

6.  Effective-substrate theory for optical reflection from a layered substrate.

Authors:  J P Landry; X Wang; Y Y Fei; X D Zhu
Journal:  J Opt Soc Am B       Date:  2008-01-01       Impact factor: 2.106

7.  Resonant Cavity Imaging: A Means Toward High-Throughput Label-Free Protein Detection.

Authors:  David A Bergstein; Emre Ozkumur; Arthur C Wu; Ayça Yalçin; Jeremy R Colson; James W Needham; Rostem J Irani; Jonathan M Gershoni; Bennett B Goldberg; Charles Delisi; Michael F Ruane; M Selim Unlü
Journal:  IEEE J Sel Top Quantum Electron       Date:  2008       Impact factor: 4.544

8.  Macromolecular scaffolds for immobilizing small molecule microarrays in label-free detection of protein-ligand interactions on solid support.

Authors:  Y S Sun; J P Landry; Y Y Fei; X D Zhu; J T Luo; X B Wang; K S Lam
Journal:  Anal Chem       Date:  2009-07-01       Impact factor: 6.986

9.  Metal-enhanced fluorescence of tryptophan residues in proteins: application toward label-free bioassays.

Authors:  Henryk Szmacinski; Krishanu Ray; Joseph R Lakowicz
Journal:  Anal Biochem       Date:  2008-11-27       Impact factor: 3.365

10.  Effect of fluorescently labeling protein probes on kinetics of protein-ligand reactions.

Authors:  Y S Sun; J P Landry; Y Y Fei; X D Zhu; J T Luo; X B Wang; K S Lam
Journal:  Langmuir       Date:  2008-12-02       Impact factor: 3.882
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