Literature DB >> 1497918

Myc and Max: a putative transcriptional complex in search of a cellular target.

R Torres1, N Schreiber-Agus, S D Morgenbesser, R A DePinho.   

Abstract

Biochemical and genetic observations have supported the hypothesis that Myc family proteins function to regulate genes important in cellular growth and differentiation. The recent findings that Myc proteins can associate with other cellular proteins, possess sequence-specific DNA-binding activity and may directly transactivate transcription of several candidate genes have provided an experimental framework in which to test the transcription factor model. Based on principles established for several well characterized viral oncoproteins, a model is presented in which the regulation of Myc function is controlled by specific cellular protein interactions that serve to activate or repress transactivation activity or deny access of the Myc complex to its target sequences.

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Year:  1992        PMID： 1497918     DOI： 10.1016/0955-0674(92)90013-3

Source DB:  PubMed          Journal:  Curr Opin Cell Biol        ISSN： 0955-0674            Impact factor:   8.382


  19 in total

1.  Expression and activity of L-Myc in normal mouse development.

Authors:  K S Hatton; K Mahon; L Chin; F C Chiu; H W Lee; D Peng; S D Morgenbesser; J Horner; R A DePinho
Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

Review 2.  Control of vertebrate development by MYC.

Authors:  Peter J Hurlin
Journal:  Cold Spring Harb Perspect Med       Date:  2013-09-01       Impact factor: 6.915

Review 3.  c-Myc target genes involved in cell growth, apoptosis, and metabolism.

Authors:  C V Dang
Journal:  Mol Cell Biol       Date:  1999-01       Impact factor: 4.272

Review 4.  The lncRNA-MYC regulatory network in cancer.

Authors:  Kaiyuan Deng; Xiaoqiang Guo; Hao Wang; Jiazeng Xia
Journal:  Tumour Biol       Date:  2014-08-20

5.  Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers.

Authors:  D L Solomon; B Amati; H Land
Journal:  Nucleic Acids Res       Date:  1993-11-25       Impact factor: 16.971

6.  Overproduction of v-Myc in the nucleus and its excess over Max are not required for avian fibroblast transformation.

Authors:  A T Tikhonenko; A R Hartman; M L Linial
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

7.  c-Myc binds to 5' flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation.

Authors:  S Mai; A Jalava
Journal:  Nucleic Acids Res       Date:  1994-06-25       Impact factor: 16.971

8.  Mad proteins contain a dominant transcription repression domain.

Authors:  D E Ayer; C D Laherty; Q A Lawrence; A P Armstrong; R N Eisenman
Journal:  Mol Cell Biol       Date:  1996-10       Impact factor: 4.272

9.  Suppression of Myc, but not E1a, transformation activity by Max-associated proteins, Mad and Mxi1.

Authors:  E G Lahoz; L Xu; N Schreiber-Agus; R A DePinho
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-07       Impact factor: 11.205

10.  TATA-binding protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1A protein.

Authors:  G Hateboer; H T Timmers; A K Rustgi; M Billaud; L J van 't Veer; R Bernards
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205
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