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Literature DB >> 8036154

c-Myc binds to 5' flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation.

Abstract

The dihydrofolate reductase is a key enzyme of the folate metabolism which supplies the cell with dTTPs for DNA synthesis. Using cellular extracts, we demonstrate the formation of c-Myc/Max heterodimers at the dihydrofolate reductase (DHFR) 5' flanking CANNTG (E-box) motifs. The presence of these complexes correlates with c-Myc levels and active cellular proliferation.

Entities: Chemical Gene

Mesh：

Substances：

Year: 1994 PMID： 8036154 PMCID： PMC523683 DOI： 10.1093/nar/22.12.2264

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

54 in total

Review 1. Myc and Max: a putative transcriptional complex in search of a cellular target.

Authors: R Torres; N Schreiber-Agus; S D Morgenbesser; R A DePinho
Journal: Curr Opin Cell Biol Date: 1992-06 Impact factor: 8.382

Review 2. myc function and regulation.

Authors: K B Marcu; S A Bossone; A J Patel
Journal: Annu Rev Biochem Date: 1992 Impact factor: 23.643

Review 3. Myc and Max function as a nucleoprotein complex.

Authors: E M Blackwood; L Kretzner; R N Eisenman
Journal: Curr Opin Genet Dev Date: 1992-04 Impact factor: 5.578

4. Antisense c-myc effects on preimplantation mouse embryo development.

Authors: B C Paria; S K Dey; G K Andrews
Journal: Proc Natl Acad Sci U S A Date: 1992-11-01 Impact factor: 11.205

5. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones.

Authors: J L Biedler; S Roffler-Tarlov; M Schachner; L S Freedman
Journal: Cancer Res Date: 1978-11 Impact factor: 12.701

6. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

Authors: J L Biedler; L Helson; B A Spengler
Journal: Cancer Res Date: 1973-11 Impact factor: 12.701

7. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors.

Authors: S Berberich; N Hyde-DeRuyscher; P Espenshade; M Cole
Journal: Oncogene Date: 1992-04 Impact factor: 9.867

8. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

Authors: B Amati; S Dalton; M W Brooks; T D Littlewood; G I Evan; H Land
Journal: Nature Date: 1992-10-01 Impact factor: 49.962

9. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.

Authors: Y Shi; J M Glynn; L J Guilbert; T G Cotter; R P Bissonnette; D R Green
Journal: Science Date: 1992-07-10 Impact factor: 47.728

10. Constitutive expression of exogenous myc in myelomonocytic cells: acquisition of a more transformed phenotype and inhibition of differentiation induction.

Authors: O Chisholm; P Stapleton; G Symonds
Journal: Oncogene Date: 1992-09 Impact factor: 9.867

12 in total

c-Myc binds to 5' flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation.

Review 1. Myc and Max: a putative transcriptional complex in search of a cellular target.

Review 2. myc function and regulation.

Review 3. Myc and Max function as a nucleoprotein complex.

4. Antisense c-myc effects on preimplantation mouse embryo development.

5. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones.

6. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture.

7. max encodes a sequence-specific DNA-binding protein and is not regulated by serum growth factors.

8. Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max.

9. Role for c-myc in activation-induced apoptotic cell death in T cell hybridomas.

10. Constitutive expression of exogenous myc in myelomonocytic cells: acquisition of a more transformed phenotype and inhibition of differentiation induction.

1. Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression.

2. Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene.

3. YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels.

Review 4. c-Myc target genes involved in cell growth, apoptosis, and metabolism.

5. Genomic instability in MycER-activated Rat1A-MycER cells.

6. The transcriptional program of a human B cell line in response to Myc.

7. Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions.

8. The c-myc protein represses the lambda 5 and TdT initiators.

9. c-Myc target gene specificity is determined by a post-DNAbinding mechanism.

10. Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells.