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Literature DB >> 1495961

At least three promoters direct expression of the mouse glucocorticoid receptor gene.

U Strähle¹, A Schmidt, G Kelsey, A F Stewart, T J Cole, W Schmid, G Schütz.

Abstract

We have characterized the gene for the mouse glucocorticoid receptor. The gene spans approximately 110 kilobases, and glucocorticoid receptor transcripts are assembled from nine exons. Expression of the gene is controlled by at least three promoters, resulting in glucocorticoid receptor transcripts with different 5' nontranslated exons. One promoter is cell-specific, found to be active only in T lymphocytes. The other two promoters are active to various degrees in all cell lines and tissues so far analyzed and are located in a CpG island. The promoter activities are accompanied by DNase I hypersensitivity sites in chromatin. In contrast to a conservation of exon-intron structure, differences in promoter organization suggest a divergence between the evolution of regulatory and coding regions among members of the steroid receptor super-family.

Entities: Disease Gene Species

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Year: 1992 PMID： 1495961 PMCID： PMC49577 DOI： 10.1073/pnas.89.15.6731

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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