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Literature DB >> 14872096

Local excitation, global inhibition mechanism for gradient sensing: an interactive applet.

Brett Kutscher¹, Peter Devreotes, Pablo A Iglesias.

Abstract

We have proposed a model in which cells detect gradients of chemoattractant by balancing a fast local excitation and a slower global inhibition. To illustrate this general mechanism, we have developed an interactive applet that mimics laboratory experiments in which either spatially homogeneous or heterogeneous stimuli of chemoattractant are applied.

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Year: 2004 PMID： 14872096 DOI： 10.1126/stke.2192004pl3

Source DB: PubMed Journal: Sci STKE ISSN： 1525-8882

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Cited

14 in total

1. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton.

Authors: Chris Janetopoulos; Lan Ma; Peter N Devreotes; Pablo A Iglesias
Journal: Proc Natl Acad Sci U S A Date: 2004-06-07 Impact factor: 11.205

2. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells.

Authors: Lan Ma; Chris Janetopoulos; Liu Yang; Peter N Devreotes; Pablo A Iglesias
Journal: Biophys J Date: 2004-10-01 Impact factor: 4.033

Review 3. Reaction-diffusion systems in intracellular molecular transport and control.

Authors: Siowling Soh; Marta Byrska; Kristiana Kandere-Grzybowska; Bartosz A Grzybowski
Journal: Angew Chem Int Ed Engl Date: 2010-06-07 Impact factor: 15.336

4. Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of Dictyostelium cells.

Authors: Liu Yang; Pablo A Iglesias
Journal: Syst Control Lett Date: 2006-04 Impact factor: 2.804

Local excitation, global inhibition mechanism for gradient sensing: an interactive applet.

1. Chemoattractant-induced phosphatidylinositol 3,4,5-trisphosphate accumulation is spatially amplified and adapts, independent of the actin cytoskeleton.

2. Two complementary, local excitation, global inhibition mechanisms acting in parallel can explain the chemoattractant-induced regulation of PI(3,4,5)P3 response in dictyostelium cells.

Review 3. Reaction-diffusion systems in intracellular molecular transport and control.

4. Positive feedback may cause the biphasic response observed in the chemoattractant-induced response of Dictyostelium cells.

5. Stochastic signal processing and transduction in chemotactic response of eukaryotic cells.

6. Wave-pinning and cell polarity from a bistable reaction-diffusion system.

7. Receptor noise limitations on chemotactic sensing.

Review 8. Chemoattractant signaling in dictyostelium: adaptation and amplification.

9. Computational model for cell morphodynamics.

Review 10. Moving in the right direction: how eukaryotic cells migrate along chemical gradients.