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Literature DB >> 14726021

Repair of DNA double strand breaks by non-homologous end joining.

Abstract

DNA double strand breaks (DSB) are the most serious form of DNA damage. If not repaired they can lead to cell death. If misrepaired DSBs contribute to chromosomal aberrations and genomic instability. Non-homologous end joining (NHEJ) is one of two major pathways for the repair of DSBs in human cells. Proteins known to be required for NHEJ include the DNA-dependent protein kinase (DNA-PK), XRCC4, DNA ligase IV, and Artemis. This review discusses how these and other accessory proteins may function in the repair of DSBs produced by ionizing radiation (IR) and by V(D)J recombination.

Entities: Chemical Gene Species

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Year: 2003 PMID： 14726021 DOI： 10.1016/j.biochi.2003.10.011

Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079

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Cited

125 in total

1. Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.

Authors: Amit Kumar; Oscar Fernandez-Capetillo; Oscar Fernadez-Capetillo; Ana C Carrera
Journal: Proc Natl Acad Sci U S A Date: 2010-04-05 Impact factor: 11.205

2. Single-Homology-Arm Linear DNA Recombination by the Nonhomologous End Joining Pathway as a Novel and Simple Gene Inactivation Method: a Proof-of-Concept Study in Dietzia sp. Strain DQ12-45-1b.

Authors: Shelian Lu; Yong Nie; Meng Wang; Hong-Xiu Xu; Dong-Ling Ma; Jie-Liang Liang; Xiao-Lei Wu
Journal: Appl Environ Microbiol Date: 2018-09-17 Impact factor: 4.792

3. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Authors: Erin R P Shull; Youngsoo Lee; Hironobu Nakane; Travis H Stracker; Jingfeng Zhao; Helen R Russell; John H J Petrini; Peter J McKinnon
Journal: Genes Dev Date: 2009-01-15 Impact factor: 11.361

Review 4. Non-homologous end joining: emerging themes and unanswered questions.

Authors: Sarvan Kumar Radhakrishnan; Nicholas Jette; Susan P Lees-Miller
Journal: DNA Repair (Amst) Date: 2014-02-26

5. A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.

Authors: Mirjam van der Burg; Hanna Ijspeert; Nicole S Verkaik; Tuba Turul; Wouter W Wiegant; Keiko Morotomi-Yano; Pierre-Olivier Mari; Ilhan Tezcan; David J Chen; Malgorzata Z Zdzienicka; Jacques J M van Dongen; Dik C van Gent
Journal: J Clin Invest Date: 2008-12-15 Impact factor: 14.808

Repair of DNA double strand breaks by non-homologous end joining.

1. Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.

2. Single-Homology-Arm Linear DNA Recombination by the Nonhomologous End Joining Pathway as a Novel and Simple Gene Inactivation Method: a Proof-of-Concept Study in Dietzia sp. Strain DQ12-45-1b.

3. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS.

Review 4. Non-homologous end joining: emerging themes and unanswered questions.

5. A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.

6. Chemotherapeutic deletion of CTG repeats in lymphoblast cells from DM1 patients.

7. BRCA2 is required for neurogenesis and suppression of medulloblastoma.

Review 8. The phosphoinositide-3-OH-kinase-related kinases of Arabidopsis thaliana.

Review 9. DNA strand breaks, neurodegeneration and aging in the brain.

Review 10. Mouse models of DNA double-strand break repair and neurological disease.