| Literature DB >> 16065066 |
George W Templeton1, Greg B G Moorhead.
Abstract
The phosphoinositide-3-OH-kinase-related kinases (PIKKs) are atypical protein kinases exclusive to eukaryotes. They mediate the cellular response to a range of stresses, including genome and RNA surveillance and availability of nutrients for growth. Orthologues of five out of the six PIKK family members are present in plant genomes. Recent studies in plant PIKKs have revealed features unique to, and in common with, other PIKKs. This review summarizes the basic knowledge of these proteins in mammals and yeast in comparison with what is known for Arabidopsis and other plants.Entities:
Mesh:
Substances:
Year: 2005 PMID: 16065066 PMCID: PMC1369146 DOI: 10.1038/sj.embor.7400479
Source DB: PubMed Journal: EMBO Rep ISSN: 1469-221X Impact factor: 8.807