Literature DB >> 14702099

Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

Pier Giuseppe Pelicci1.   

Abstract

Stem/progenitor cells ensure tissue and organism homeostasis and might represent a frequent target of transformation. Although these cells are potentially immortal, their life span is restrained by signaling pathways (p19-p53; p16-Rb) that are activated by DNA damage (telomere dysfunction, environmental stresses) and lead to senescence or apoptosis. Execution of these checkpoint programs might lead to stem cell depletion and organism aging, while their inactivation contributes to tumor formation.

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Mesh：

Year:  2004        PMID： 14702099      PMCID： PMC300887          DOI： 10.1172/JCI20750

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  34 in total

1.  Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation.

Authors:  Anna V Molofsky; Ricardo Pardal; Toshihide Iwashita; In-Kyung Park; Michael F Clarke; Sean J Morrison
Journal:  Nature       Date:  2003-10-22       Impact factor: 49.962

Review 2.  When cells get stressed: an integrative view of cellular senescence.

Authors:  Ittai Ben-Porath; Robert A Weinberg
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

Review 3.  Bmi1, stem cells, and senescence regulation.

Authors:  In-Kyung Park; Sean J Morrison; Michael F Clarke
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

Review 4.  Cellular senescence in cancer treatment: friend or foe?

Authors:  Pascal Kahlem; Bernd Dörken; Clemens A Schmitt
Journal:  J Clin Invest       Date:  2004-01       Impact factor: 14.808

5.  Telomerase maintains telomere structure in normal human cells.

Authors:  Kenkichi Masutomi; Evan Y Yu; Shilagardy Khurts; Ittai Ben-Porath; Jennifer L Currier; Geoffrey B Metz; Mary W Brooks; Shuichi Kaneko; Seishi Murakami; James A DeCaprio; Robert A Weinberg; Sheila A Stewart; William C Hahn
Journal:  Cell       Date:  2003-07-25       Impact factor: 41.582

6.  Prospective identification of tumorigenic breast cancer cells.

Authors:  Muhammad Al-Hajj; Max S Wicha; Adalberto Benito-Hernandez; Sean J Morrison; Michael F Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-10       Impact factor: 11.205

7.  Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts.

Authors:  Simona Parrinello; Enrique Samper; Ana Krtolica; Joshua Goldstein; Simon Melov; Judith Campisi
Journal:  Nat Cell Biol       Date:  2003-08       Impact factor: 28.824

Review 8.  Normal and leukemic hematopoiesis: are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?

Authors:  Emmanuelle Passegué; Catriona H M Jamieson; Laurie E Ailles; Irving L Weissman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-09-22       Impact factor: 11.205

9.  Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing.

Authors:  Kwok-Kin Wong; Richard S Maser; Robert M Bachoo; Jayant Menon; Daniel R Carrasco; Yansong Gu; Frederick W Alt; Ronald A DePinho
Journal:  Nature       Date:  2003-01-22       Impact factor: 49.962

10.  Specific association of human telomerase activity with immortal cells and cancer.

Authors:  N W Kim; M A Piatyszek; K R Prowse; C B Harley; M D West; P L Ho; G M Coviello; W E Wright; S L Weinrich; J W Shay
Journal:  Science       Date:  1994-12-23       Impact factor: 47.728
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  28 in total

Review 1.  Using mice to examine p53 functions in cancer, aging, and longevity.

Authors:  Lawrence A Donehower
Journal:  Cold Spring Harb Perspect Biol       Date:  2009-11-04       Impact factor: 10.005

2.  Global heterochromatin loss: a unifying theory of aging?

Authors:  Amy Tsurumi; Willis X Li
Journal:  Epigenetics       Date:  2012-07-01       Impact factor: 4.528

3.  Simulating mouse mammary gland development: cell ageing and its relation to stem and progenitor activity.

Authors:  A Paguirigan; D J Beebe; C M Alexander
Journal:  Cell Prolif       Date:  2007-02       Impact factor: 6.831

Review 4.  DNA double-strand breaks: a potential causative factor for mammalian aging?

Authors:  Han Li; James R Mitchell; Paul Hasty
Journal:  Mech Ageing Dev       Date:  2008-02-14       Impact factor: 5.432

Review 5.  Adult stem cell maintenance and tissue regeneration in the ageing context: the role for A-type lamins as intrinsic modulators of ageing in adult stem cells and their niches.

Authors:  Vanja Pekovic; Christopher J Hutchison
Journal:  J Anat       Date:  2008-07       Impact factor: 2.610

Review 6.  Replicative stress, stem cells and aging.

Authors:  Yaroslava Ruzankina; Amma Asare; Eric J Brown
Journal:  Mech Ageing Dev       Date:  2008-03-28       Impact factor: 5.432

Review 7.  Aging stem cells, latexin, and longevity.

Authors:  Ying Liang; Gary Van Zant
Journal:  Exp Cell Res       Date:  2008-02-19       Impact factor: 3.905

8.  Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss.

Authors:  Yaroslava Ruzankina; Carolina Pinzon-Guzman; Amma Asare; Tony Ong; Laura Pontano; George Cotsarelis; Valerie P Zediak; Marielena Velez; Avinash Bhandoola; Eric J Brown
Journal:  Cell Stem Cell       Date:  2007-06-07       Impact factor: 24.633

Review 9.  The convergence of fracture repair and stem cells: interplay of genes, aging, environmental factors and disease.

Authors:  Michael Hadjiargyrou; Regis J O'Keefe
Journal:  J Bone Miner Res       Date:  2014-11       Impact factor: 6.741

Review 10.  Molecular mechanism of extrinsic factors affecting anti-aging of stem cells.

Authors:  Tzyy Yue Wong; Mairim Alexandra Solis; Ying-Hui Chen; Lynn Ling-Huei Huang
Journal:  World J Stem Cells       Date:  2015-03-26       Impact factor: 5.326
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