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Literature DB >> 14722606

Cellular senescence in cancer treatment: friend or foe?

Pascal Kahlem¹, Bernd Dörken, Clemens A Schmitt.

Abstract

Damage to DNA, the prime target of anticancer therapy, triggers programmed cellular responses. In addition to apoptosis, therapy-mediated premature senescence has been identified as another drug-responsive program that impacts the outcome of cancer therapy. Here, we discuss whether induction of senescence is a beneficial or, rather, a detrimental consequence of the therapeutic intervention.

Entities: Disease

Mesh：

Substances：

Year: 2004 PMID： 14722606 PMCID： PMC311442 DOI： 10.1172/JCI20784

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

54 in total

1. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

Authors: N H Chehab; A Malikzay; E S Stavridi; T D Halazonetis
Journal: Proc Natl Acad Sci U S A Date: 1999-11-23 Impact factor: 11.205

2. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage.

Authors: K Webley; J A Bond; C J Jones; J P Blaydes; A Craig; T Hupp; D Wynford-Thomas
Journal: Mol Cell Biol Date: 2000-04 Impact factor: 4.272

3. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.

Authors: R Agami; R Bernards
Journal: Cell Date: 2000-07-07 Impact factor: 41.582

4. Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging.

Authors: Luc-Marie Gerland; Simone Peyrol; Christophe Lallemand; Robert Branche; Jean-Pierre Magaud; Martine Ffrench
Journal: Exp Gerontol Date: 2003-08 Impact factor: 4.032

5. pRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73.

Authors: Kamilah Alexander; Hai-Su Yang; Philip W Hinds
Journal: Mol Cancer Res Date: 2003-08 Impact factor: 5.852

Review 6. p53, the cellular gatekeeper for growth and division.

Authors: A J Levine
Journal: Cell Date: 1997-02-07 Impact factor: 41.582

7. DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling.

Authors: A R Tee; C G Proud
Journal: Oncogene Date: 2000-06-15 Impact factor: 9.867

8. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

Authors: Gabriella D'Orazi; Barbara Cecchinelli; Tiziana Bruno; Isabella Manni; Yuichiro Higashimoto; Shin'ichi Saito; Monica Gostissa; Sabrina Coen; Alessandra Marchetti; Giannino Del Sal; Guilia Piaggio; Maurizio Fanciulli; Ettore Appella; Silvia Soddu
Journal: Nat Cell Biol Date: 2002-01 Impact factor: 28.824

9. Genetic analysis of chemoresistance in primary murine lymphomas.

Authors: C A Schmitt; C T Rosenthal; S W Lowe
Journal: Nat Med Date: 2000-09 Impact factor: 53.440

10. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

Authors: K Oda; H Arakawa; T Tanaka; K Matsuda; C Tanikawa; T Mori; H Nishimori; K Tamai; T Tokino; Y Nakamura; Y Taya
Journal: Cell Date: 2000-09-15 Impact factor: 41.582

42 in total

Review 1. Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

Authors: Pier Giuseppe Pelicci
Journal: J Clin Invest Date: 2004-01 Impact factor: 14.808

Review 2. Senescence and life span.

Authors: Peter J Hornsby
Journal: Pflugers Arch Date: 2009-09-08 Impact factor: 3.657

Cellular senescence in cancer treatment: friend or foe?

1. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage.

2. Posttranslational modifications of p53 in replicative senescence overlapping but distinct from those induced by DNA damage.

3. Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage.

4. Association of increased autophagic inclusions labeled for beta-galactosidase with fibroblastic aging.

5. pRb inactivation in senescent cells leads to an E2F-dependent apoptosis requiring p73.

Review 6. p53, the cellular gatekeeper for growth and division.

7. DNA-damaging agents cause inactivation of translational regulators linked to mTOR signalling.

8. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.

9. Genetic analysis of chemoresistance in primary murine lymphomas.

10. p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53.

Review 1. Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?

Review 2. Senescence and life span.

Review 3. Cellular senescence and cancer chemotherapy resistance.

4. Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells.

5. Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest.

Review 6. The multifaceted role of exosomes in cancer progression: diagnostic and therapeutic implications [corrected].

7. Radiation-inducible immunotherapy for cancer: senescent tumor cells as a cancer vaccine.

8. Significance of cellular senescence in aging and cancer.

9. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG.

10. The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation.