Literature DB >> 14698199

Synthesis and biological activity of new quinoxaline antibiotics of echinomycin analogues.

Yun Bong Kim1, Yong Hae Kim, Ju Youn Park, Soo Kie Kim.   

Abstract

Novel quinoxaline antibiotics having the methylenedithioether bridge as an analogue of echinomycin have been synthesized by insertion of methylene moiety between -S-S- bond. The compound 1a shows remarkable cytotoxicities against human tumor various cell lines, and is active VRE (vancomycin-resistant enterococci) within MIC range 0.5-8 microg/mL. According to the eukaryotic or prokaryotic data, 1a might be a first analogue to replace echinomycin.

Entities:  

Mesh：

Substances：

Year:  2004        PMID： 14698199     DOI： 10.1016/j.bmcl.2003.09.086

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  25 in total

1.  rac-(2R,3S)-2-Phenyl-3-(3-phenyl-1,2,3,4-tetra-hydro-quinoxalin-2-yl)quinoxaline.

Authors:  Sven Ammermann; Constantin Daniliuc; Peter G Jones; Wolf-Walther du Mont; Hans-Hermann Johannes
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2008-06-07

2.  One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes.

Authors:  Priyabrata Roy; Binay Krishna Ghorai
Journal:  Beilstein J Org Chem       Date:  2010-05-25       Impact factor: 2.883

3.  4-[3-(4-Fluoro-phen-yl)quinoxalin-2-yl]-N-isopropyl-pyridin-2-amine.

Authors:  Pierre Koch; Dieter Schollmeyer; Stefan Laufer
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-05-20

4.  3-(4-Fluoro-phen-yl)-6-meth-oxy-2-(4-pyrid-yl)quinoxaline.

Authors:  Hartmut Jahns; Pierre Koch; Dieter Schollmeyer; Stefan Laufer
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-06-20

5.  Highly efficient synthesis of quinoxaline derivatives from 1,2-benzenediamine and α-aminoxylated 1,3-dicarbonyl compounds.

Authors:  Jianwei Yan; Yanhong Xu; Fangfang Zhuang; Jie Tian; Guisheng Zhang
Journal:  Mol Divers       Date:  2016-01-21       Impact factor: 2.943

6.  Synthesis, characterization, in vitro SAR study, and preliminary in vivo toxicity evaluation of naphthylmethyl substituted bis-imidazolium salts.

Authors:  Marie R Southerland; Michael A DeBord; Nicholas A Johnson; Steven R Crabtree; Nicolas E Alexander; Michael L Stromyer; Patrick O Wagers; Matthew J Panzner; Chrys Wesdemiotis; Leah P Shriver; Claire A Tessier; Wiley J Youngs
Journal:  Bioorg Med Chem       Date:  2020-11-28       Impact factor: 3.641

7.  An efficient protocol for the synthesis of quinoxaline derivatives at room temperature using recyclable alumina-supported heteropolyoxometalates.

Authors:  Diego M Ruiz; Juan C Autino; Nancy Quaranta; Patricia G Vázquez; Gustavo P Romanelli
Journal:  ScientificWorldJournal       Date:  2012-03-12

8.  2-[3-(2-Acetoxyphenyl)quinoxa-lin-2-yl]phenyl acetate.

Authors:  Dan-Feng Shen; Shao-Jie Lou; Dan-Qian Xu
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-04-20

9.  3-[2-(3-Phenyl-2-oxo-1,2-di-hydro-quin-oxalin-1-yl)eth-yl]-1,3-oxazolidin-2-one.

Authors:  Ballo Daouda; Mouhamadou Lamine Doumbia; El Mokhtar Essassi; Mohamed Saadi; Lahcen El Ammari
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-04-05

10.  A one-pot catalyst-free synthesis of functionalized pyrrolo[1,2-a]quinoxaline derivatives from benzene-1,2-diamine, acetylenedicarboxylates and ethyl bromopyruvate.

Authors:  Mohammad Piltan; Loghman Moradi; Golaleh Abasi; Seyed Amir Zarei
Journal:  Beilstein J Org Chem       Date:  2013-03-11       Impact factor: 2.883
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.