Implantable telemeter for long-term electroneurographic recordings in animals and humans.

A system is described that amplifies an electroneurographic signal (ENG) from a tripolar electrode nerve cuff and transmits it from the implanted amplifier to an external drive box. The output was raw ENG, bandpass filtered from 800 to 8000 Hz. The implant was powered by radio-frequency induction and operated for coil-to-coil separations up to 30 mm. The testing and performance of the system is described. The input-referred noise was never more than 1 microV RMS, and, at some positions of the radio-frequency field, was 0.7 microV, close to the expected value for the amplifier used. The common-mode rejection ratio (CMRR) depended on the impedance imbalance from the cuff and the length of input cable. Devices with a short cable and low source impedance had CMRR of 84 dB, but, with 31 cm of cable and a real cuff, the CMRR fell to 66 dB. Recovery from a stimulus artifact took 5 ms. The responses of the cuff to external potential gradients and to common-mode signals are described theoretically or by simulation. The devices are available for use in neuroprosthetic or neurophysiological research.