Literature DB >> 14682769

Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.

Norikazu Nishino1, Binoy Jose, Shinji Okamura, Shutoku Ebisusaki, Tamaki Kato, Yuko Sumida, Minoru Yoshida.   

Abstract

New inhibitors of histone deacetylase (HDAC) containing a sulfhydryl group were designed on the basis of the corresponding hydroxamic acid (CHAP31) and FK228. Their disulfide dimers and hybrids exhibited potent HDAC inhibitory activity in vivo with potential as anticancer prodrugs. [structure: see text]

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Year:  2003        PMID： 14682769     DOI： 10.1021/ol036098e

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  7 in total

Review 1.  Isoform-selective histone deacetylase inhibitors.

Authors:  Anton V Bieliauskas; Mary Kay H Pflum
Journal:  Chem Soc Rev       Date:  2008-05-08       Impact factor: 54.564

2.  Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.

Authors:  Jared R Mays; José A Restituyo; Rebeccah J Katzenberger; David A Wassarman; Scott R Rajski
Journal:  Tetrahedron Lett       Date:  2007-06-25       Impact factor: 2.415

3.  Real-time imaging of histone H4 hyperacetylation in living cells.

Authors:  Kazuki Sasaki; Tamaki Ito; Norikazu Nishino; Saadi Khochbin; Minoru Yoshida
Journal:  Proc Natl Acad Sci U S A       Date:  2009-09-03       Impact factor: 11.205

4.  Modulation of Activity Profiles for Largazole-Based HDAC Inhibitors through Alteration of Prodrug Properties.

Authors:  Lilibeth A Salvador; Heekwang Park; Fatma H Al-Awadhi; Yanxia Liu; Bumki Kim; Sabrina L Zeller; Qi-Yin Chen; Jiyong Hong; Hendrik Luesch
Journal:  ACS Med Chem Lett       Date:  2014-07-07       Impact factor: 4.345

5.  Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold.

Authors:  Albert A Bowers; Nathan West; Tenaya L Newkirk; Annie E Troutman-Youngman; Stuart L Schreiber; Olaf Wiest; James E Bradner; Robert M Williams
Journal:  Org Lett       Date:  2009-03-19       Impact factor: 6.005

Review 6.  Zinc binding groups for histone deacetylase inhibitors.

Authors:  Lei Zhang; Jian Zhang; Qixiao Jiang; Li Zhang; Weiguo Song
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

7.  Improved development of mouse somatic cell nuclear transfer embryos by chlamydocin analogues, class I and IIa histone deacetylase inhibitors†.

Authors:  Satoshi Kamimura; Kimiko Inoue; Eiji Mizutani; Jin-Moon Kim; Hiroki Inoue; Narumi Ogonuki; Kei Miyamoto; Shunya Ihashi; Nobuhiko Itami; Teruhiko Wakayama; Akihiro Ito; Norikazu Nishino; Minoru Yoshida; Atsuo Ogura
Journal:  Biol Reprod       Date:  2021-08-03       Impact factor: 4.285
  7 in total

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