Literature DB >> 18575573

Cyclic Disulfides as Functional Mimics of the Histone Deacetylase Inhibitor FK-228.

Jared R Mays1, José A Restituyo, Rebeccah J Katzenberger, David A Wassarman, Scott R Rajski.   

Abstract

FK-228 is a potent histone deacetylase (HDAC) inhibitor with tremendous therapeutic potential against a wide array of human cancers. We describe the development of analogs that share FK-228's novel mechanism of activation and HDAC inhibition.

Entities:  

Year:  2007        PMID： 18575573      PMCID： PMC2084391          DOI： 10.1016/j.tetlet.2007.04.123

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  30 in total

1.  A non-isotopic assay for histone deacetylase activity.

Authors:  K Hoffmann; G Brosch; P Loidl; M Jung
Journal:  Nucleic Acids Res       Date:  1999-05-01       Impact factor: 16.971

Review 2.  Deacetylase enzymes: biological functions and the use of small-molecule inhibitors.

Authors:  Christina M Grozinger; Stuart L Schreiber
Journal:  Chem Biol       Date:  2002-01

Review 3.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer.

Authors:  Saverio Minucci; Pier Giuseppe Pelicci
Journal:  Nat Rev Cancer       Date:  2006-01       Impact factor: 60.716

Review 4.  Histone acetylation and chromatin assembly: a single escort, multiple dances?

Authors:  S Y Roth; C D Allis
Journal:  Cell       Date:  1996-10-04       Impact factor: 41.582

Review 5.  Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

Authors:  C A Hassig; S L Schreiber
Journal:  Curr Opin Chem Biol       Date:  1997-10       Impact factor: 8.822

Review 6.  Understanding and controlling the cell cycle with natural products.

Authors:  D T Hung; T F Jamison; S L Schreiber
Journal:  Chem Biol       Date:  1996-08

Review 7.  HIF-1 and mechanisms of hypoxia sensing.

Authors:  G L Semenza
Journal:  Curr Opin Cell Biol       Date:  2001-04       Impact factor: 8.382

8.  seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties.

Authors:  J Rudolph; H Theis; R Hanke; R Endermann; L Johannsen; F Geschke
Journal:  J Med Chem       Date:  2001-02-15       Impact factor: 7.446

9.  Total synthesis of spiruchostatin A, a potent histone deacetylase inhibitor.

Authors:  Alexander Yurek-George; Fay Habens; Matthew Brimmell; Graham Packham; A Ganesan
Journal:  J Am Chem Soc       Date:  2004-02-04       Impact factor: 15.419

10.  Therapeutic attack of hypoxic cells of solid tumors: presidential address.

Authors:  A C Sartorelli
Journal:  Cancer Res       Date:  1988-02-15       Impact factor: 12.701
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  2 in total

Review 1.  Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma.

Authors:  Karen M VanderMolen; William McCulloch; Cedric J Pearce; Nicholas H Oberlies
Journal:  J Antibiot (Tokyo)       Date:  2011-05-18       Impact factor: 2.649

2.  Efficient preparation of unsymmetrical disulfides by nickel-catalyzed reductive coupling strategy.

Authors:  Fei Wang; Ying Chen; Weidong Rao; Lutz Ackermann; Shun-Yi Wang
Journal:  Nat Commun       Date:  2022-05-11       Impact factor: 17.694
  2 in total

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