| Literature DB >> 14638509 |
Raymond Cha1, William J Brown, Michael J Rybak.
Abstract
In search of treatment alternatives against vancomycin-resistant S. aureus (VRSA), an in vitro pharmacodynamic model with simulated endocardial vegetations incorporating protein and a high inoculum was used to simulate daptomycin, linezolid, quinupristin-dalfopristin, and vancomycin against the Michigan VRSA strain. Daptomycin and quinupristin-dalfopristin exhibited the greatest bacterial reductions, and all tested agents except vancomycin exhibited bactericidal activity against the VRSA.Entities:
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Year: 2003 PMID: 14638509 PMCID: PMC296181 DOI: 10.1128/AAC.47.12.3960-3963.2003
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191