Literature DB >> 14623180

Single-cell analysis of lambda immunity regulation.

Kristoffer Baek1, Sine Svenningsen, Harvey Eisen, Kim Sneppen, Stanley Brown.   

Abstract

We have examined expression of the lambdacI operon in single cells via a rex Colon, two colons gfp substitution. Although average fluorescence agreed with expectations for expression of lambda-repressor, fluorescence fluctuated greatly from cell-to-cell. Fluctuations in repressor concentration are not predicted by previous models and are tolerated in part by a regulatory response to DNA damage.

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Year:  2003        PMID: 14623180     DOI: 10.1016/j.jmb.2003.09.037

Source DB:  PubMed          Journal:  J Mol Biol        ISSN: 0022-2836            Impact factor:   5.469


  28 in total

1.  Single-cell behavior and population heterogeneity: solving an inverse problem to compute the intrinsic physiological state functions.

Authors:  Konstantinos Spetsieris; Kyriacos Zygourakis
Journal:  J Biotechnol       Date:  2011-09-14       Impact factor: 3.307

2.  Stability and instability in the lysogenic state of phage lambda.

Authors:  John W Little; Christine B Michalowski
Journal:  J Bacteriol       Date:  2010-09-24       Impact factor: 3.490

3.  A quantitative study of lambda-phage SWITCH and its components.

Authors:  Chunbo Lou; Xiaojing Yang; Xili Liu; Bin He; Qi Ouyang
Journal:  Biophys J       Date:  2007-01-26       Impact factor: 4.033

4.  From single-cell genetic architecture to cell population dynamics: quantitatively decomposing the effects of different population heterogeneity sources for a genetic network with positive feedback architecture.

Authors:  Nikos V Mantzaris
Journal:  Biophys J       Date:  2007-03-23       Impact factor: 4.033

5.  DNA looping provides stability and robustness to the bacteriophage lambda switch.

Authors:  Marco J Morelli; Pieter Rein Ten Wolde; Rosalind J Allen
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-01       Impact factor: 11.205

6.  Effect of supercoiling on the λ switch.

Authors:  Kamilla Norregaard; Magnus Andersson; Kim Sneppen; Peter Eigil Nielsen; Stanley Brown; Lene B Oddershede
Journal:  Bacteriophage       Date:  2014-01-01

7.  DNA supercoiling enhances cooperativity and efficiency of an epigenetic switch.

Authors:  Kamilla Norregaard; Magnus Andersson; Kim Sneppen; Peter Eigil Nielsen; Stanley Brown; Lene B Oddershede
Journal:  Proc Natl Acad Sci U S A       Date:  2013-10-07       Impact factor: 11.205

8.  Detailed genomic analysis of the Wbeta and gamma phages infecting Bacillus anthracis: implications for evolution of environmental fitness and antibiotic resistance.

Authors:  Raymond Schuch; Vincent A Fischetti
Journal:  J Bacteriol       Date:  2006-04       Impact factor: 3.490

9.  Lambda-prophage induction modeled as a cooperative failure mode of lytic repression.

Authors:  Nicholas Chia; Ido Golding; Nigel Goldenfeld
Journal:  Phys Rev E Stat Nonlin Soft Matter Phys       Date:  2009-09-01

Review 10.  The bacteriophage lambda CI protein finds an asymmetric solution.

Authors:  Ann Hochschild; Mitchell Lewis
Journal:  Curr Opin Struct Biol       Date:  2009-01-30       Impact factor: 6.809

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