| Literature DB >> 14606629 |
Miguel Pita1, José Luis Fernandez, Jaime Gosálvez.
Abstract
We present a technique (W-CGH) based on Comparative Genomic Hybridization (CGH), but using whole DNA probes, which permits the identification of chromosomal polymorphisms related to highly repetitive DNA sequences that exist between the two genomes compared. The procedure employs two differently colored whole DNA probes from two different individuals that are mixed and hybridized to metaphase chromosomes. The method provides a simple way to map whole genome differences for highly repetitive DNA sequences between two individuals, since it does not require chromosome-specific probes.Entities:
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Year: 2003 PMID: 14606629 DOI: 10.1023/a:1025937726614
Source DB: PubMed Journal: Chromosome Res ISSN: 0967-3849 Impact factor: 4.620