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Literature DB >> 9012398

Polymorphisms in drug-metabolizing enzymes: what is their clinical relevance and why do they exist?

D W Nebert.

Abstract

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Year: 1997 PMID： 9012398 PMCID： PMC1712416

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

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Review 2. Evolution of the P450 gene superfamily: animal-plant 'warfare', molecular drive and human genetic differences in drug oxidation.

Authors: F J Gonzalez; D W Nebert
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3. Nomenclature for human CYP2D6 alleles.

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4. The origin of mutants.

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5. Causes of death before birth.

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Review 6. Cytochrome P450: evolution and functional diversity.

Authors: D W Nebert; R A McKinnon
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Review 7. Pharmacogenetic phenotyping and genotyping. Present status and future potential.

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Review 8. P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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9. Black swallowtail (Papilio polyxenes) alleles encode cytochrome P450s that selectively metabolize linear furanocoumarins.

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10. Genetic relationship of human populations and ethnic differences in reaction to drugs and food.

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