Literature DB >> 145756

Carcinogenicity of N-nitrosopyrrolidine: dose-response study in rats.

R Preussmann, D Schmähl, G Eisenbrand.   

Abstract

Results from a dose-response study in rats are reported, in which daily oral doses of 10, 3, 1, and 0.3 mg/kg bodyweight/day respectively were administered. The three highest dose levels resulted in incidences of liver cancer of 46, 84, and 32% respectively. In the lowest dose group (0.3 mg/kg/day) no statistically significant increase in tumor rate compared to untreated controls was found.

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Year:  1977        PMID: 145756     DOI: 10.1007/bf00285322

Source DB:  PubMed          Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol        ISSN: 0084-5353


  12 in total

1.  [QUANTITATIVE ANALYSIS OF THE CARCINOGENIC EFFECT OF DIETHYLNITROSAMINE].

Authors:  H DRUCKREY; A SCHILDBACH; D SCHMAEHL; R PREUSSMANN; S IVANKOVIC
Journal:  Arzneimittelforschung       Date:  1963-10

2.  N-Nitrosodimethylamine in air.

Authors:  D H Fine; D P Rounbehler; E D Pellizzari; J E Bunch; R W Berkley; J McCrae; J T Bursey; E Sawicki; K Krost; G A DeMarrais
Journal:  Bull Environ Contam Toxicol       Date:  1976-06       Impact factor: 2.151

3.  Nitrosamine studies: neoplasms of liver and genital mesothelium in nitrosopyrrolidine-treated MRC rats.

Authors:  M Greenblatt; W Lijinsky
Journal:  J Natl Cancer Inst       Date:  1972-06       Impact factor: 13.506

4.  [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors:  H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal:  Z Krebsforsch       Date:  1967

5.  Carcinogenesis in different animal specids by diethylnitrosamine.

Authors:  D Schmähl; H Osswald
Journal:  Experientia       Date:  1967-06-15

6.  Failure to induce tumors in Swiss mice after concurrent administration of amino acids and sodium nitrite.

Authors:  M Greenblatt; W Lijinsky
Journal:  J Natl Cancer Inst       Date:  1972-05       Impact factor: 13.506

7.  Guidelines for experiments to predict the degree of safety of a material for man.

Authors:  C S Weil
Journal:  Toxicol Appl Pharmacol       Date:  1972-02       Impact factor: 4.219

8.  Experimental studies on the organotropic effect of nitrosamines in the respiratory tract.

Authors:  W Dontenwill
Journal:  Food Cosmet Toxicol       Date:  1968-12

9.  Carcinogenicity testing of low doses of nitrosopyrrolidine and of nitrosobenzthiazuron and nitrosocarbaryl in rats.

Authors:  R Preussmann; G Eisenbrand; D Schmähl
Journal:  IARC Sci Publ       Date:  1976

10.  Induction of kidney tumours in the rat with dimethylnitrosamine (N-nitrosodimethylamine).

Authors:  P N MAGEE; J M BARNES
Journal:  J Pathol Bacteriol       Date:  1962-07
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  6 in total

1.  Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.

Authors:  N Ito; T Shirai; S Fukushima; M Hirose
Journal:  J Cancer Res Clin Oncol       Date:  1984       Impact factor: 4.553

2.  The problem of thresholds in chemical carcinogenesis some views on theoretical and practical aspects.

Authors:  R Preussmann
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

3.  Carcinogenic effect of low doses of nitrosopyrrolidine administered in drinking water to Syrian golden hamsters.

Authors:  M B Ketkar; P Schneider; R Preussmann; Ch Plass; U Mohr
Journal:  J Cancer Res Clin Oncol       Date:  1982       Impact factor: 4.553

Review 4.  Carcinogenic N-nitroso compounds and their environmental significance.

Authors:  R Preussmann
Journal:  Naturwissenschaften       Date:  1984-01

5.  Interference of acetoxyalkyl-nitrosamines with limb bud differentiation in organ culture.

Authors:  R Stahlmann; U Bluth; M Wiessler; D Neubert
Journal:  Arch Toxicol       Date:  1983-10       Impact factor: 5.153

6.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031

  6 in total

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