Literature DB >> 6746710

Dose-response study of urinary bladder carcinogenesis in rats by N-butyl-N-(4-hydroxybutyl)nitrosamine.

N Ito, T Shirai, S Fukushima, M Hirose.   

Abstract

A dose-response study was carried out in male F344 rats with a specific urinary bladder carcinogen, N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN), which was administered as a solution in drinking water for up to 112 weeks. BBN was given in four different concentrations, 50, 10, 5, and 1 ppm, to groups of 30 rats. The highest dose induced urinary bladder cancer in all rats treated by week 91, decreasing yields being associated with lower dose levels: an incidence of 76.7% was observed with 10 ppm, followed by 20.0% with 5 ppm. The lowest dose (1 ppm) only induced two cases of papilloma (6.9%).

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Year:  1984        PMID： 6746710     DOI： 10.1007/BF00390992

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  26 in total

1.  Synergistic effect of urinary bladder carcinogenesis in rats treated with N-butyl-n-(4-hydroxybutyl)nitrosamine, N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide,N-2-fluorenylacetamide, and 3,3'-dichlorobenzidine.

Authors:  H Tsuda; Y Miyata; G Murasaki; H Kinoshita; S Fukushima
Journal:  Gan       Date:  1977-04

2.  Development of urinary bladder cancer in the rat.

Authors:  E Kunze
Journal:  Curr Top Pathol       Date:  1979

3.  Effect of unilateral ureter ligation on development of tumors in the urinary system of rats treated with N-butyl-N-(4-hydroxybutyl)nitrosoamine.

Authors:  N Ito; S Makiura; Y Yokota; Y Kamamoto; Y Hiasa
Journal:  Gan       Date:  1971-10

4.  Different susceptibilities of the urinary bladder epithelium of animal species to three nitroso compounds.

Authors:  M Hirose; S Fukushima; M Hananouchi; T Shirai; T Ogiso
Journal:  Gan       Date:  1976-04

5.  Promoting effects of sodium L-ascorbate on two-stage urinary bladder carcinogenesis in rats.

Authors:  S Fukushima; K Imaida; T Sakata; T Okamura; M Shibata; N Ito
Journal:  Cancer Res       Date:  1983-09       Impact factor: 12.701

6.  Histopathological analysis of preneoplastic changes during N-butyl-N-(4-hydroxybutyl)-nitrosamine-induced urinary bladder carcinogenesis in rats.

Authors:  S Fukushima; G Murasaki; M Hirose; K Nakanishi; R Hasegawa; N Ito
Journal:  Acta Pathol Jpn       Date:  1982-03

7.  Spontaneous tumors in F-344/DuCrj rats.

Authors:  A Maekawa; Y Kurokawa; M Takahashi; T Kokubo; T Ogiu; H Onodera; H Tanigawa; Y Ohno; F Furukawa; Y Hayashi
Journal:  Gan       Date:  1983-06

8.  Urinary bladder tumors induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in dogs.

Authors:  E Okajima; T Hiramatsu; K Hirao; M Ijuin; Y Hirao; K Babaya; S Ikuma; S Ohara; T Shiomi; T Hijioka; H Ohishi
Journal:  Cancer Res       Date:  1981-05       Impact factor: 12.701

9.  Carcinogenicity of N-nitroso compounds. Species and route differences in regard to organotropism.

Authors:  D Schmähl; M Habs
Journal:  Oncology       Date:  1980       Impact factor: 2.935

10.  Hepatic pathology in rats on low dietary levels of dimethylnitrosamine.

Authors:  B Terracini; P N Magee; J M Barnes
Journal:  Br J Cancer       Date:  1967-09       Impact factor: 7.640
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  4 in total

1.  Detection of carcinogen-induced bladder cancer by fluorocoxib A.

Authors:  Jennifer Bourn; Kusum Rathore; Robert Donnell; Wesley White; Md Jashim Uddin; Lawrence Marnett; Maria Cekanova
Journal:  BMC Cancer       Date:  2019-11-27       Impact factor: 4.430

Review 2.  Predicting the carcinogenicity of chemicals in humans from rodent bioassay data.

Authors:  G Goodman; R Wilson
Journal:  Environ Health Perspect       Date:  1991-08       Impact factor: 9.031

3.  Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice.

Authors:  S Tamano; A Hagiwara; E Suzuki; M Okada; T Shirai; S Fukushima
Journal:  Jpn J Cancer Res       Date:  1991-06

4.  Renal pelvic carcinoma which shows metastatic potential to distant organs, induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice.

Authors:  T Murai; S Mori; M Hosono; Y Takeuchi; T Ohara; S Makino; R Takeda; Y Hayashi; S Fukushima
Journal:  Jpn J Cancer Res       Date:  1991-12
  4 in total

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