Literature DB >> 7130251

Carcinogenic effect of low doses of nitrosopyrrolidine administered in drinking water to Syrian golden hamsters.

M B Ketkar, P Schneider, R Preussmann, Ch Plass, U Mohr.   

Abstract

Three groups of Syrian golden hamsters each consisting of 30 males and 30 females were given three different doses of nitrosopyrrolidine in their drinking water for the duration of their lives. The animals mainly showed hepatocellular neoplasms. Males were more affected than females and tumor incidence was found to be dose-dependent. No liver tumors were seen in females that received the lowest dose.

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Year:  1982        PMID： 7130251     DOI： 10.1007/bf00402055

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  8 in total

1.  Carcinogenicity of N-nitrosopyrrolidine: dose-response study in rats.

Authors:  R Preussmann; D Schmähl; G Eisenbrand
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1977-11-18

2.  Nitrosamine studies: neoplasms of liver and genital mesothelium in nitrosopyrrolidine-treated MRC rats.

Authors:  M Greenblatt; W Lijinsky
Journal:  J Natl Cancer Inst       Date:  1972-06       Impact factor: 13.506

3.  [Organotropic carcinogenic effects of 65 various N-nitroso- compounds on BD rats].

Authors:  H Druckrey; R Preussmann; S Ivankovic; D Schmähl
Journal:  Z Krebsforsch       Date:  1967

4.  Failure to induce tumors in Swiss mice after concurrent administration of amino acids and sodium nitrite.

Authors:  M Greenblatt; W Lijinsky
Journal:  J Natl Cancer Inst       Date:  1972-05       Impact factor: 13.506

5.  Experimental studies on the organotropic effect of nitrosamines in the respiratory tract.

Authors:  W Dontenwill
Journal:  Food Cosmet Toxicol       Date:  1968-12

6.  The effect of substituents on the carcinogenicity of n-nitrosopyrrolidine in Sprague-Dawley rats.

Authors:  W Lijinsky; H W Taylor
Journal:  Cancer Res       Date:  1976-06       Impact factor: 12.701

7.  Carcinogenicity testing of low doses of nitrosopyrrolidine and of nitrosobenzthiazuron and nitrosocarbaryl in rats.

Authors:  R Preussmann; G Eisenbrand; D Schmähl
Journal:  IARC Sci Publ       Date:  1976

8.  Effect of the intermittent administration of N-nitrosopyrrolidine (NPYR) on the tumor incidence in Sprague-Dawley rats.

Authors:  M Habs; H Habs; D Schmähi
Journal:  Int J Cancer       Date:  1980-07-15       Impact factor: 7.396
  8 in total
  1 in total

Review 1.  Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

Authors:  L S Gold; M de Veciana; G M Backman; R Magaw; P Lopipero; M Smith; M Blumenthal; R Levinson; L Bernstein; B N Ames
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031
  1 in total

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